Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

Autophagy defects are implicated in multiple late-onset neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s, Huntington’s, and Parkinson’s diseases. Since aging is the most common shared risk factor in neurodegeneration, we assessed rates of autophagy in mammalia...

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Detalles Bibliográficos
Autores principales: Stavoe, Andrea KH, Gopal, Pallavi P, Gubas, Andrea, Tooze, Sharon A, Holzbaur, Erika LF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634969/
https://www.ncbi.nlm.nih.gov/pubmed/31309927
http://dx.doi.org/10.7554/eLife.44219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634969/
https://www.ncbi.nlm.nih.gov/pubmed/31309927
http://dx.doi.org/10.7554/eLife.44219

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