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Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D

PURPOSE OF REVIEW: Although checkpoint inhibitor blockade is now widely used clinically for cancer immunotherapy, the reverse process, (i.e. induction of checkpoints to slow autoimmunity) has not been extensively explored. CD8 T-cell exhaustion is a state of immune hyporesponsiveness that may be har...

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Detalles Bibliográficos
Autores principales:	Linsley, Peter S., Long, S. Alice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott, Williams & Wilkins 2019
Materias:	DIABETES AND ENDOCHRINE PANCREAS II: Edited by Peter A. Gottlieb
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635062/ https://www.ncbi.nlm.nih.gov/pubmed/31157632 http://dx.doi.org/10.1097/MED.0000000000000488

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