The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis

With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 va...

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Detalles Bibliográficos
Autores principales: Tong, Yu, Ye, Lv, Li, Shiping, Zhao, Fengyan, Ying, Junjie, Qu, Yi, Li, Jinhui, Mu, Dezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635291/
https://www.ncbi.nlm.nih.gov/pubmed/31277128
http://dx.doi.org/10.1097/MD.0000000000016205
Descripción
Sumario:With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 variants in 8q24 and glioma risk. Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10(–35), OR = 3.54). In particular, both homozygous GG (P = 1.91 × 10(–3), OR1 = 2.01) and heterozygous GT (P = 7.75 × 10(–10), OR2 = 1.35) genotypes of rs4295627 were associated with glioma risk. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of glioma.

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