The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis

With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 va...

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Autores principales: Tong, Yu, Ye, Lv, Li, Shiping, Zhao, Fengyan, Ying, Junjie, Qu, Yi, Li, Jinhui, Mu, Dezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635291/
https://www.ncbi.nlm.nih.gov/pubmed/31277128
http://dx.doi.org/10.1097/MD.0000000000016205
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author Tong, Yu
Ye, Lv
Li, Shiping
Zhao, Fengyan
Ying, Junjie
Qu, Yi
Li, Jinhui
Mu, Dezhi
author_facet Tong, Yu
Ye, Lv
Li, Shiping
Zhao, Fengyan
Ying, Junjie
Qu, Yi
Li, Jinhui
Mu, Dezhi
author_sort Tong, Yu
collection PubMed
description With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 variants in 8q24 and glioma risk. Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10(–35), OR = 3.54). In particular, both homozygous GG (P = 1.91 × 10(–3), OR1 = 2.01) and heterozygous GT (P = 7.75 × 10(–10), OR2 = 1.35) genotypes of rs4295627 were associated with glioma risk. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of glioma.
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spelling pubmed-66352912019-08-01 The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis Tong, Yu Ye, Lv Li, Shiping Zhao, Fengyan Ying, Junjie Qu, Yi Li, Jinhui Mu, Dezhi Medicine (Baltimore) Research Article With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 variants in 8q24 and glioma risk. Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10(–35), OR = 3.54). In particular, both homozygous GG (P = 1.91 × 10(–3), OR1 = 2.01) and heterozygous GT (P = 7.75 × 10(–10), OR2 = 1.35) genotypes of rs4295627 were associated with glioma risk. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of glioma. Wolters Kluwer Health 2019-07-05 /pmc/articles/PMC6635291/ /pubmed/31277128 http://dx.doi.org/10.1097/MD.0000000000016205 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Tong, Yu
Ye, Lv
Li, Shiping
Zhao, Fengyan
Ying, Junjie
Qu, Yi
Li, Jinhui
Mu, Dezhi
The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis
title The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis
title_full The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis
title_fullStr The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis
title_full_unstemmed The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis
title_short The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis
title_sort association of 6 variants of 8q24 and the risk of glioma: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635291/
https://www.ncbi.nlm.nih.gov/pubmed/31277128
http://dx.doi.org/10.1097/MD.0000000000016205
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