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Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin a-1 (Tα-1) was proposed as a single molecule-based...

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Detalles Bibliográficos
Autores principales: Armirotti, Andrea, Tomati, Valeria, Matthes, Elizabeth, Veit, Guido, Cholon, Deborah M., Phuan, Puay-Wah, Braccia, Clarissa, Guidone, Daniela, Gentzsch, Martina, Lukacs, Gergely L., Verkman, Alan S., Galietta, Luis J. V., Hanrahan, John W., Pedemonte, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635361/
https://www.ncbi.nlm.nih.gov/pubmed/31311979
http://dx.doi.org/10.1038/s41598-019-46639-1

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