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The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide pol...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635366/ https://www.ncbi.nlm.nih.gov/pubmed/31311932 http://dx.doi.org/10.1038/s41467-019-10902-w |
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author | Hong, Shaodong Liu, Dongbing Luo, Shuzhen Fang, Wenfeng Zhan, Jianhua Fu, Sha Zhang, Yaxiong Wu, Xuan Zhou, Huaqiang Chen, Xi Chen, Gang Zhang, Zhonghan Zheng, Qiufan Li, Xiaobo Chen, Jinghao Liu, Xingmin Lei, Mengyue Ye, Chen Wang, Jian Yang, Huanming Xu, Xun Zhu, Shida Yang, Yunpeng Zhao, Yuanyuan Zhou, Ningning Zhao, Hongyun Huang, Yan Zhang, Lanjun Wu, Kui Zhang, Li |
author_facet | Hong, Shaodong Liu, Dongbing Luo, Shuzhen Fang, Wenfeng Zhan, Jianhua Fu, Sha Zhang, Yaxiong Wu, Xuan Zhou, Huaqiang Chen, Xi Chen, Gang Zhang, Zhonghan Zheng, Qiufan Li, Xiaobo Chen, Jinghao Liu, Xingmin Lei, Mengyue Ye, Chen Wang, Jian Yang, Huanming Xu, Xun Zhu, Shida Yang, Yunpeng Zhao, Yuanyuan Zhou, Ningning Zhao, Hongyun Huang, Yan Zhang, Lanjun Wu, Kui Zhang, Li |
author_sort | Hong, Shaodong |
collection | PubMed |
description | Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide polymorphism arrays. We identify a low degree of somatic mutation but widespread existence of copy number variations. We reveal predominant signature 2 mutations and frequent loss of type I interferon genes that are involved in the host-virus counteraction. Integrated analysis shows enrichment of genetic lesions affecting several critical pathways, including NF-κB, JAK/STAT, and cell cycle. Notably, multi-dimensional comparison unveils that pulmonary LELC resemble NPC but are clearly different from other lung cancers, natural killer/T-cell lymphoma or EBV-related gastric cancer in terms of genetic features. In all, our study illustrates a distinct genomic landscape of pulmonary LELC and provides a road map to facilitate genome-guided personalized treatment. |
format | Online Article Text |
id | pubmed-6635366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66353662019-07-18 The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma Hong, Shaodong Liu, Dongbing Luo, Shuzhen Fang, Wenfeng Zhan, Jianhua Fu, Sha Zhang, Yaxiong Wu, Xuan Zhou, Huaqiang Chen, Xi Chen, Gang Zhang, Zhonghan Zheng, Qiufan Li, Xiaobo Chen, Jinghao Liu, Xingmin Lei, Mengyue Ye, Chen Wang, Jian Yang, Huanming Xu, Xun Zhu, Shida Yang, Yunpeng Zhao, Yuanyuan Zhou, Ningning Zhao, Hongyun Huang, Yan Zhang, Lanjun Wu, Kui Zhang, Li Nat Commun Article Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide polymorphism arrays. We identify a low degree of somatic mutation but widespread existence of copy number variations. We reveal predominant signature 2 mutations and frequent loss of type I interferon genes that are involved in the host-virus counteraction. Integrated analysis shows enrichment of genetic lesions affecting several critical pathways, including NF-κB, JAK/STAT, and cell cycle. Notably, multi-dimensional comparison unveils that pulmonary LELC resemble NPC but are clearly different from other lung cancers, natural killer/T-cell lymphoma or EBV-related gastric cancer in terms of genetic features. In all, our study illustrates a distinct genomic landscape of pulmonary LELC and provides a road map to facilitate genome-guided personalized treatment. Nature Publishing Group UK 2019-07-16 /pmc/articles/PMC6635366/ /pubmed/31311932 http://dx.doi.org/10.1038/s41467-019-10902-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hong, Shaodong Liu, Dongbing Luo, Shuzhen Fang, Wenfeng Zhan, Jianhua Fu, Sha Zhang, Yaxiong Wu, Xuan Zhou, Huaqiang Chen, Xi Chen, Gang Zhang, Zhonghan Zheng, Qiufan Li, Xiaobo Chen, Jinghao Liu, Xingmin Lei, Mengyue Ye, Chen Wang, Jian Yang, Huanming Xu, Xun Zhu, Shida Yang, Yunpeng Zhao, Yuanyuan Zhou, Ningning Zhao, Hongyun Huang, Yan Zhang, Lanjun Wu, Kui Zhang, Li The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
title | The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
title_full | The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
title_fullStr | The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
title_full_unstemmed | The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
title_short | The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
title_sort | genomic landscape of epstein-barr virus-associated pulmonary lymphoepithelioma-like carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635366/ https://www.ncbi.nlm.nih.gov/pubmed/31311932 http://dx.doi.org/10.1038/s41467-019-10902-w |
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