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The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma

Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide pol...

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Autores principales: Hong, Shaodong, Liu, Dongbing, Luo, Shuzhen, Fang, Wenfeng, Zhan, Jianhua, Fu, Sha, Zhang, Yaxiong, Wu, Xuan, Zhou, Huaqiang, Chen, Xi, Chen, Gang, Zhang, Zhonghan, Zheng, Qiufan, Li, Xiaobo, Chen, Jinghao, Liu, Xingmin, Lei, Mengyue, Ye, Chen, Wang, Jian, Yang, Huanming, Xu, Xun, Zhu, Shida, Yang, Yunpeng, Zhao, Yuanyuan, Zhou, Ningning, Zhao, Hongyun, Huang, Yan, Zhang, Lanjun, Wu, Kui, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635366/
https://www.ncbi.nlm.nih.gov/pubmed/31311932
http://dx.doi.org/10.1038/s41467-019-10902-w
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author Hong, Shaodong
Liu, Dongbing
Luo, Shuzhen
Fang, Wenfeng
Zhan, Jianhua
Fu, Sha
Zhang, Yaxiong
Wu, Xuan
Zhou, Huaqiang
Chen, Xi
Chen, Gang
Zhang, Zhonghan
Zheng, Qiufan
Li, Xiaobo
Chen, Jinghao
Liu, Xingmin
Lei, Mengyue
Ye, Chen
Wang, Jian
Yang, Huanming
Xu, Xun
Zhu, Shida
Yang, Yunpeng
Zhao, Yuanyuan
Zhou, Ningning
Zhao, Hongyun
Huang, Yan
Zhang, Lanjun
Wu, Kui
Zhang, Li
author_facet Hong, Shaodong
Liu, Dongbing
Luo, Shuzhen
Fang, Wenfeng
Zhan, Jianhua
Fu, Sha
Zhang, Yaxiong
Wu, Xuan
Zhou, Huaqiang
Chen, Xi
Chen, Gang
Zhang, Zhonghan
Zheng, Qiufan
Li, Xiaobo
Chen, Jinghao
Liu, Xingmin
Lei, Mengyue
Ye, Chen
Wang, Jian
Yang, Huanming
Xu, Xun
Zhu, Shida
Yang, Yunpeng
Zhao, Yuanyuan
Zhou, Ningning
Zhao, Hongyun
Huang, Yan
Zhang, Lanjun
Wu, Kui
Zhang, Li
author_sort Hong, Shaodong
collection PubMed
description Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide polymorphism arrays. We identify a low degree of somatic mutation but widespread existence of copy number variations. We reveal predominant signature 2 mutations and frequent loss of type I interferon genes that are involved in the host-virus counteraction. Integrated analysis shows enrichment of genetic lesions affecting several critical pathways, including NF-κB, JAK/STAT, and cell cycle. Notably, multi-dimensional comparison unveils that pulmonary LELC resemble NPC but are clearly different from other lung cancers, natural killer/T-cell lymphoma or EBV-related gastric cancer in terms of genetic features. In all, our study illustrates a distinct genomic landscape of pulmonary LELC and provides a road map to facilitate genome-guided personalized treatment.
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spelling pubmed-66353662019-07-18 The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma Hong, Shaodong Liu, Dongbing Luo, Shuzhen Fang, Wenfeng Zhan, Jianhua Fu, Sha Zhang, Yaxiong Wu, Xuan Zhou, Huaqiang Chen, Xi Chen, Gang Zhang, Zhonghan Zheng, Qiufan Li, Xiaobo Chen, Jinghao Liu, Xingmin Lei, Mengyue Ye, Chen Wang, Jian Yang, Huanming Xu, Xun Zhu, Shida Yang, Yunpeng Zhao, Yuanyuan Zhou, Ningning Zhao, Hongyun Huang, Yan Zhang, Lanjun Wu, Kui Zhang, Li Nat Commun Article Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide polymorphism arrays. We identify a low degree of somatic mutation but widespread existence of copy number variations. We reveal predominant signature 2 mutations and frequent loss of type I interferon genes that are involved in the host-virus counteraction. Integrated analysis shows enrichment of genetic lesions affecting several critical pathways, including NF-κB, JAK/STAT, and cell cycle. Notably, multi-dimensional comparison unveils that pulmonary LELC resemble NPC but are clearly different from other lung cancers, natural killer/T-cell lymphoma or EBV-related gastric cancer in terms of genetic features. In all, our study illustrates a distinct genomic landscape of pulmonary LELC and provides a road map to facilitate genome-guided personalized treatment. Nature Publishing Group UK 2019-07-16 /pmc/articles/PMC6635366/ /pubmed/31311932 http://dx.doi.org/10.1038/s41467-019-10902-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hong, Shaodong
Liu, Dongbing
Luo, Shuzhen
Fang, Wenfeng
Zhan, Jianhua
Fu, Sha
Zhang, Yaxiong
Wu, Xuan
Zhou, Huaqiang
Chen, Xi
Chen, Gang
Zhang, Zhonghan
Zheng, Qiufan
Li, Xiaobo
Chen, Jinghao
Liu, Xingmin
Lei, Mengyue
Ye, Chen
Wang, Jian
Yang, Huanming
Xu, Xun
Zhu, Shida
Yang, Yunpeng
Zhao, Yuanyuan
Zhou, Ningning
Zhao, Hongyun
Huang, Yan
Zhang, Lanjun
Wu, Kui
Zhang, Li
The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
title The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
title_full The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
title_fullStr The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
title_full_unstemmed The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
title_short The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
title_sort genomic landscape of epstein-barr virus-associated pulmonary lymphoepithelioma-like carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635366/
https://www.ncbi.nlm.nih.gov/pubmed/31311932
http://dx.doi.org/10.1038/s41467-019-10902-w
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