Cargando…

p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration

Cell migration is essential to embryonic development, wound healing, and cancer cell dissemination. Cells move via leading-edge protrusion, substrate adhesion, and retraction of the cell's rear. The molecular mechanisms by which extracellular cues signal to the actomyosin cytoskeleton to contro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Samson, Shiela C., Elliott, Andrew, Mueller, Brian D., Kim, Yung, Carney, Keith R., Bergman, Jared P., Blenis, John, Mendoza, Michelle C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635457/ https://www.ncbi.nlm.nih.gov/pubmed/31138649 http://dx.doi.org/10.1074/jbc.RA119.007431

Ejemplares similares

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I
por: Sevrieva, Ivanka R., et al.
Publicado: (2020)

Skeletal Muscle Protein Tyrosine Phosphatase 1B Regulates Insulin Sensitivity in African Americans
por: Stull, April J., et al.
Publicado: (2012)

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
por: Fukushima, Atsushi, et al.
Publicado: (2010)

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
por: Oriente, Francesco, et al.
Publicado: (2011)

Protein Phosphatase 1-α Regulates AS160 Ser(588) and Thr(642) Dephosphorylation in Skeletal Muscle
por: Sharma, Pragya, et al.
Publicado: (2016)

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity
por: Burmeister, Brian T., et al.
Publicado: (2015)

Heat Shock Protein 90 Inhibitors Reduce Trafficking of ATP-gated P2X1 Receptors and Human Platelet Responsiveness
por: Lalo, Ulyana, et al.
Publicado: (2012)

Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
por: Maile, Laura A., et al.
Publicado: (2008)

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
por: Keshwani, Malik M., et al.
Publicado: (2011)

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation
por: Staples, Christopher J., et al.
Publicado: (2010)

Distinct Docking Mechanisms Mediate Interactions between the Msg5 Phosphatase and Mating or Cell Integrity Mitogen-activated Protein Kinases (MAPKs) in Saccharomyces cerevisiae
por: Palacios, Lorena, et al.
Publicado: (2011)

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
por: Dickinson, Robin J., et al.
Publicado: (2011)

WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)
por: Gangula, Narmadha Reddy, et al.
Publicado: (2013)

Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)
por: Geetha, Nishamol, et al.
Publicado: (2011)

Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases
por: Caunt, Christopher J., et al.
Publicado: (2008)

Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation
por: Choudhuri, Kaushik, et al.
Publicado: (2009)

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance : The Medical Research Council Ely Prospective Study 1990–2000
por: Forouhi, Nita G., et al.
Publicado: (2008)

Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase
por: Simone, Simona, et al.
Publicado: (2008)

Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
por: Morino, Katsutaro, et al.
Publicado: (2008)

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
por: Senokuchi, Takafumi, et al.
Publicado: (2008)

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
por: Wang, Zhong Q., et al.
Publicado: (2008)

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
por: Deng, Jen-Ying, et al.
Publicado: (2008)

siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle
por: Austin, Reginald L., et al.
Publicado: (2008)

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
por: Klöting, Nora, et al.
Publicado: (2008)

Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36
por: Rogers, Pamela M., et al.
Publicado: (2008)

Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor γ Coactivator-1α in Hepatic Insulin Resistance
por: Kumashiro, Naoki, et al.
Publicado: (2008)

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes
por: Regazzetti, Claire, et al.
Publicado: (2009)

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
por: Nieto-Vazquez, Iria, et al.
Publicado: (2008)

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
por: Xie, Zhonglin, et al.
Publicado: (2008)

Differential Distribution, Clustering, and Lateral Diffusion of Subtypes of the Inositol 1,4,5-Trisphosphate Receptor
por: Pantazaka, Evangelia, et al.
Publicado: (2011)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)(536) Phosphorylation
por: Zhao, Yanhua, et al.
Publicado: (2011)

Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways: ROLE OF A PHOSPHOLIPASE A(2)(cPLA(2))/CYCLOOXYGENASE-2 (COX-2)/PROSTACYCLIN RECEPTOR-DEPENDENT AUTOCRINE LOOP
por: Deacon, Karl, et al.
Publicado: (2010)

A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase
por: Bamberger, Martina, et al.
Publicado: (2011)

Identification of Human P2X1 Receptor-interacting Proteins Reveals a Role of the Cytoskeleton in Receptor Regulation
por: Lalo, Ulyana, et al.
Publicado: (2011)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice
por: Huang, Ping, et al.
Publicado: (2011)

Cysteine Scanning Mutagenesis (Residues Glu(52)–Gly(96)) of the Human P2X1 Receptor for ATP: MAPPING AGONIST BINDING AND CHANNEL GATING
por: Allsopp, Rebecca C., et al.
Publicado: (2011)

Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8
por: Delint-Ramirez, Ilse, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_mf5njhqhq7jjn0d0u7ninpqg6r