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Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography

Limited in part by the spatial resolution of typical in vivo magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined desc...

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Autores principales: Xia, Xiaoluan, Fan, Lingzhong, Hou, Bing, Zhang, Baogui, Zhang, Dan, Cheng, Chen, Deng, Hongxia, Dong, Yunyun, Zhao, Xudong, Li, Haifang, Jiang, Tianzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635473/
https://www.ncbi.nlm.nih.gov/pubmed/31354418
http://dx.doi.org/10.3389/fnins.2019.00709
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author Xia, Xiaoluan
Fan, Lingzhong
Hou, Bing
Zhang, Baogui
Zhang, Dan
Cheng, Chen
Deng, Hongxia
Dong, Yunyun
Zhao, Xudong
Li, Haifang
Jiang, Tianzi
author_facet Xia, Xiaoluan
Fan, Lingzhong
Hou, Bing
Zhang, Baogui
Zhang, Dan
Cheng, Chen
Deng, Hongxia
Dong, Yunyun
Zhao, Xudong
Li, Haifang
Jiang, Tianzi
author_sort Xia, Xiaoluan
collection PubMed
description Limited in part by the spatial resolution of typical in vivo magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined description of the Acb using non-invasive neuroimaging technologies and approaches. In this study, high-resolution ex vivo macaque brain diffusion MRI data were acquired to investigate the tractography-based parcellation of the Acb. Our results identified a shell-core-like partitioning in macaques that is similar to that in humans as well as an alternative solution that subdivided the Acb into four parcels, the medial shell, the lateral shell, the ventral core, and the dorsal core. Furthermore, we characterized the specific anatomical and functional connectivity profiles of these Acb subregions and generalized their specialized functions to establish a fine-grained macaque Acb brainnetome atlas. This atlas should be helpful in neuroimaging, stereotactic surgery, and comparative neuroimaging studies to reveal the neurophysiological substrates of various diseases and cognitive functions associated with the Acb.
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spelling pubmed-66354732019-07-26 Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography Xia, Xiaoluan Fan, Lingzhong Hou, Bing Zhang, Baogui Zhang, Dan Cheng, Chen Deng, Hongxia Dong, Yunyun Zhao, Xudong Li, Haifang Jiang, Tianzi Front Neurosci Neuroscience Limited in part by the spatial resolution of typical in vivo magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined description of the Acb using non-invasive neuroimaging technologies and approaches. In this study, high-resolution ex vivo macaque brain diffusion MRI data were acquired to investigate the tractography-based parcellation of the Acb. Our results identified a shell-core-like partitioning in macaques that is similar to that in humans as well as an alternative solution that subdivided the Acb into four parcels, the medial shell, the lateral shell, the ventral core, and the dorsal core. Furthermore, we characterized the specific anatomical and functional connectivity profiles of these Acb subregions and generalized their specialized functions to establish a fine-grained macaque Acb brainnetome atlas. This atlas should be helpful in neuroimaging, stereotactic surgery, and comparative neuroimaging studies to reveal the neurophysiological substrates of various diseases and cognitive functions associated with the Acb. Frontiers Media S.A. 2019-07-10 /pmc/articles/PMC6635473/ /pubmed/31354418 http://dx.doi.org/10.3389/fnins.2019.00709 Text en Copyright © 2019 Xia, Fan, Hou, Zhang, Zhang, Cheng, Deng, Dong, Zhao, Li and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Xia, Xiaoluan
Fan, Lingzhong
Hou, Bing
Zhang, Baogui
Zhang, Dan
Cheng, Chen
Deng, Hongxia
Dong, Yunyun
Zhao, Xudong
Li, Haifang
Jiang, Tianzi
Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography
title Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography
title_full Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography
title_fullStr Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography
title_full_unstemmed Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography
title_short Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography
title_sort fine-grained parcellation of the macaque nucleus accumbens by high-resolution diffusion tensor tractography
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635473/
https://www.ncbi.nlm.nih.gov/pubmed/31354418
http://dx.doi.org/10.3389/fnins.2019.00709
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