Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their...

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Detalles Bibliográficos
Autores principales: Fan, Xuehui, Sun, Tianyi, Crawford, William, Tan, Xiaoqiu, Ou, Xianhong, Terrar, Derek A., Ebert, Steven N., Lei, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635595/
https://www.ncbi.nlm.nih.gov/pubmed/31354504
http://dx.doi.org/10.3389/fphys.2019.00713
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author Fan, Xuehui
Sun, Tianyi
Crawford, William
Tan, Xiaoqiu
Ou, Xianhong
Terrar, Derek A.
Ebert, Steven N.
Lei, Ming
author_facet Fan, Xuehui
Sun, Tianyi
Crawford, William
Tan, Xiaoqiu
Ou, Xianhong
Terrar, Derek A.
Ebert, Steven N.
Lei, Ming
author_sort Fan, Xuehui
collection PubMed
description In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca(2+) transient properties, and potential role in localized adrenergic signaling are discussed.
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spelling pubmed-66355952019-07-26 Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives Fan, Xuehui Sun, Tianyi Crawford, William Tan, Xiaoqiu Ou, Xianhong Terrar, Derek A. Ebert, Steven N. Lei, Ming Front Physiol Physiology In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca(2+) transient properties, and potential role in localized adrenergic signaling are discussed. Frontiers Media S.A. 2019-07-10 /pmc/articles/PMC6635595/ /pubmed/31354504 http://dx.doi.org/10.3389/fphys.2019.00713 Text en Copyright © 2019 Fan, Sun, Crawford, Tan, Ou, Terrar, Ebert and Lei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Fan, Xuehui
Sun, Tianyi
Crawford, William
Tan, Xiaoqiu
Ou, Xianhong
Terrar, Derek A.
Ebert, Steven N.
Lei, Ming
Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_full Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_fullStr Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_full_unstemmed Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_short Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_sort pnmt-derived cardiomyocytes: anatomical localization, function and future perspectives
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635595/
https://www.ncbi.nlm.nih.gov/pubmed/31354504
http://dx.doi.org/10.3389/fphys.2019.00713
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