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Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases

The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely studied inflammasome and has become a hot topic of recent research. As a macromolecular complex, the NLRP3 inflammasome is activated to produce downstream factors, including caspase-1, IL-1β, and IL-18, which...

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Autores principales: An, Na, Gao, Yonghong, Si, Zeyu, Zhang, Hanlai, Wang, Liqin, Tian, Chao, Yuan, Mengchen, Yang, Xinyu, Li, Xinye, Shang, Hongcai, Xiong, Xingjiang, Xing, Yanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635885/
https://www.ncbi.nlm.nih.gov/pubmed/31354731
http://dx.doi.org/10.3389/fimmu.2019.01592
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author An, Na
Gao, Yonghong
Si, Zeyu
Zhang, Hanlai
Wang, Liqin
Tian, Chao
Yuan, Mengchen
Yang, Xinyu
Li, Xinye
Shang, Hongcai
Xiong, Xingjiang
Xing, Yanwei
author_facet An, Na
Gao, Yonghong
Si, Zeyu
Zhang, Hanlai
Wang, Liqin
Tian, Chao
Yuan, Mengchen
Yang, Xinyu
Li, Xinye
Shang, Hongcai
Xiong, Xingjiang
Xing, Yanwei
author_sort An, Na
collection PubMed
description The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely studied inflammasome and has become a hot topic of recent research. As a macromolecular complex, the NLRP3 inflammasome is activated to produce downstream factors, including caspase-1, IL-1β, and IL-18, which then promote local inflammatory responses and induce pyroptosis, leading to unfavorable effects. A growing number of studies have examined the relationship between the NLRP3 inflammasome and cardiovascular diseases (CVDs). However, some studies have shown that the NLRP3 inflammasome is not involved in the occurrence of certain diseases. Therefore, identifying the mechanism of action of the NLRP3 inflammasome and its potential involvement in the pathological process of disease progression is of utmost importance. This review discusses the mechanisms of NLRP3 inflammasome activation and the relationship between the inflammasome and CVDs, including coronary atherosclerosis, myocardial ischemia/reperfusion, cardiomyopathies, and arrhythmia, as well as CVD-related treatments.
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spelling pubmed-66358852019-07-26 Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases An, Na Gao, Yonghong Si, Zeyu Zhang, Hanlai Wang, Liqin Tian, Chao Yuan, Mengchen Yang, Xinyu Li, Xinye Shang, Hongcai Xiong, Xingjiang Xing, Yanwei Front Immunol Immunology The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely studied inflammasome and has become a hot topic of recent research. As a macromolecular complex, the NLRP3 inflammasome is activated to produce downstream factors, including caspase-1, IL-1β, and IL-18, which then promote local inflammatory responses and induce pyroptosis, leading to unfavorable effects. A growing number of studies have examined the relationship between the NLRP3 inflammasome and cardiovascular diseases (CVDs). However, some studies have shown that the NLRP3 inflammasome is not involved in the occurrence of certain diseases. Therefore, identifying the mechanism of action of the NLRP3 inflammasome and its potential involvement in the pathological process of disease progression is of utmost importance. This review discusses the mechanisms of NLRP3 inflammasome activation and the relationship between the inflammasome and CVDs, including coronary atherosclerosis, myocardial ischemia/reperfusion, cardiomyopathies, and arrhythmia, as well as CVD-related treatments. Frontiers Media S.A. 2019-07-10 /pmc/articles/PMC6635885/ /pubmed/31354731 http://dx.doi.org/10.3389/fimmu.2019.01592 Text en Copyright © 2019 An, Gao, Si, Zhang, Wang, Tian, Yuan, Yang, Li, Shang, Xiong and Xing. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
An, Na
Gao, Yonghong
Si, Zeyu
Zhang, Hanlai
Wang, Liqin
Tian, Chao
Yuan, Mengchen
Yang, Xinyu
Li, Xinye
Shang, Hongcai
Xiong, Xingjiang
Xing, Yanwei
Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases
title Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases
title_full Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases
title_fullStr Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases
title_full_unstemmed Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases
title_short Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases
title_sort regulatory mechanisms of the nlrp3 inflammasome, a novel immune-inflammatory marker in cardiovascular diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635885/
https://www.ncbi.nlm.nih.gov/pubmed/31354731
http://dx.doi.org/10.3389/fimmu.2019.01592
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