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Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus

BACKGROUND: Thyroid dysfunction has been widely reported to be more common in patients with type 2 diabetes mellitus (T2DM) in various parts of the world; however, there is paucity of data on this in our environment. OBJECTIVE: The aim of this study was to determine the possible relationship between...

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Autores principales: Ogbonna, SU, Ezeani, IU, Okafor, CI, Chinenye, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635896/
https://www.ncbi.nlm.nih.gov/pubmed/31372021
http://dx.doi.org/10.2147/DMSO.S204836
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author Ogbonna, SU
Ezeani, IU
Okafor, CI
Chinenye, S
author_facet Ogbonna, SU
Ezeani, IU
Okafor, CI
Chinenye, S
author_sort Ogbonna, SU
collection PubMed
description BACKGROUND: Thyroid dysfunction has been widely reported to be more common in patients with type 2 diabetes mellitus (T2DM) in various parts of the world; however, there is paucity of data on this in our environment. OBJECTIVE: The aim of this study was to determine the possible relationship between glycemic status and thyroid dysfunction. METHODOLOGY: A total of 354 T2DM patients and 118 non-diabetic persons (controls) were recruited for the study. A pretested questionnaire was filled for each subject after due explanations. Their blood samples were tested for HbA1c, fT3, fT4, and TSH. Information retrieved from patient's medical records included age at diagnosis of diabetes (DM) and duration of DM. Testing statistics done included Student's t-test, chi square test, and regression analysis. P-value of less than 0.05 was taken to be statistically significant. RESULTS: The results show that 43.5% and 37.3% of T2DM and control subjects, respectively, were males. Mean HbA1c was significantly higher in T2DM patients than in the controls (7.8±2.0% vs 5.8±1.2%, p=0.001), while mean fT3 was significantly lower in T2DM patients than in the controls (2.3±1.5 pg/mL vs 2.7±2.2 pg/mL, p=0.03). Mean HbA1c was significantly higher in T2DM patients with thyroid dysfunction compared to their euthyroid counterparts (8.1±1.9% vs 5.1±1.2%, p=0.001). HbA1c had a positive linear relationship with the presence of thyroid dysfunction (regression coefficient=1.89, p=0.001). CONCLUSION: There was a positive linear relationship between HbA1c and the presence of thyroid dysfunction in the T2DM patients in this study. There was an inverse relationship between HbA1c and serum fT3.
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spelling pubmed-66358962019-08-01 Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus Ogbonna, SU Ezeani, IU Okafor, CI Chinenye, S Diabetes Metab Syndr Obes Original Research BACKGROUND: Thyroid dysfunction has been widely reported to be more common in patients with type 2 diabetes mellitus (T2DM) in various parts of the world; however, there is paucity of data on this in our environment. OBJECTIVE: The aim of this study was to determine the possible relationship between glycemic status and thyroid dysfunction. METHODOLOGY: A total of 354 T2DM patients and 118 non-diabetic persons (controls) were recruited for the study. A pretested questionnaire was filled for each subject after due explanations. Their blood samples were tested for HbA1c, fT3, fT4, and TSH. Information retrieved from patient's medical records included age at diagnosis of diabetes (DM) and duration of DM. Testing statistics done included Student's t-test, chi square test, and regression analysis. P-value of less than 0.05 was taken to be statistically significant. RESULTS: The results show that 43.5% and 37.3% of T2DM and control subjects, respectively, were males. Mean HbA1c was significantly higher in T2DM patients than in the controls (7.8±2.0% vs 5.8±1.2%, p=0.001), while mean fT3 was significantly lower in T2DM patients than in the controls (2.3±1.5 pg/mL vs 2.7±2.2 pg/mL, p=0.03). Mean HbA1c was significantly higher in T2DM patients with thyroid dysfunction compared to their euthyroid counterparts (8.1±1.9% vs 5.1±1.2%, p=0.001). HbA1c had a positive linear relationship with the presence of thyroid dysfunction (regression coefficient=1.89, p=0.001). CONCLUSION: There was a positive linear relationship between HbA1c and the presence of thyroid dysfunction in the T2DM patients in this study. There was an inverse relationship between HbA1c and serum fT3. Dove 2019-07-12 /pmc/articles/PMC6635896/ /pubmed/31372021 http://dx.doi.org/10.2147/DMSO.S204836 Text en © 2019 Ogbonna et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ogbonna, SU
Ezeani, IU
Okafor, CI
Chinenye, S
Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_full Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_fullStr Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_full_unstemmed Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_short Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_sort association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635896/
https://www.ncbi.nlm.nih.gov/pubmed/31372021
http://dx.doi.org/10.2147/DMSO.S204836
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