HIV, immune activation and salt-sensitive hypertension (HISH): a research proposal

OBJECTIVE: The objective of this study is to quantify and compare the effect of excess dietary salt on immune cell activation and blood pressure in HIV versus HIV negative individuals. RESULTS: Salt-sensitivity is associated with increased immune cell activation in animal studies. This concept has n...

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Detalles Bibliográficos
Autores principales: Masenga, Sepiso K., Hamooya, Benson M., Nzala, Selestine, Kwenda, Geoffrey, Heimburger, Douglas C., Mutale, Wilbroad, Koethe, John R., Kirabo, Annet, Munsaka, Sody M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636142/
https://www.ncbi.nlm.nih.gov/pubmed/31311574
http://dx.doi.org/10.1186/s13104-019-4470-2
Descripción
Sumario:OBJECTIVE: The objective of this study is to quantify and compare the effect of excess dietary salt on immune cell activation and blood pressure in HIV versus HIV negative individuals. RESULTS: Salt-sensitivity is associated with increased immune cell activation in animal studies. This concept has not been tested in people living with HIV. This study will therefore add more information in elucidating the interaction between HIV infection and/or anti-retroviral therapy (ART), immune-activation/inflammation and hypertension. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-019-4470-2) contains supplementary material, which is available to authorized users.

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