Cargando…

Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis

Purpose: The aim of this meta-analysis was to investigate polymorphism of Bsm1, Apal, Taq1 and Cdx-2 in vitamin D receptor (VDR) associations in relation to lung cancer (LC) susceptibility. Methods: 9 literatures were recruited into this meta-analysis from PubMed, PMC, Embase, Web of Science, Cochra...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Meng, Liu, Xinyu, Liu, Na, Yang, Tian, Shi, Puyu, He, Ruiqing, Chen, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636285/
https://www.ncbi.nlm.nih.gov/pubmed/31333781
http://dx.doi.org/10.7150/jca.33431
_version_ 1783436036457627648
author Li, Meng
Liu, Xinyu
Liu, Na
Yang, Tian
Shi, Puyu
He, Ruiqing
Chen, Mingwei
author_facet Li, Meng
Liu, Xinyu
Liu, Na
Yang, Tian
Shi, Puyu
He, Ruiqing
Chen, Mingwei
author_sort Li, Meng
collection PubMed
description Purpose: The aim of this meta-analysis was to investigate polymorphism of Bsm1, Apal, Taq1 and Cdx-2 in vitamin D receptor (VDR) associations in relation to lung cancer (LC) susceptibility. Methods: 9 literatures were recruited into this meta-analysis from PubMed, PMC, Embase, Web of Science, Cochrane library and CNKI. STATA version 15.1 was used for statistical tests. The heterogeneity was tested using I(2) statistics. According to the value of I(2), the random-effect model (REM) or fixed-effect model (FEM) was selected to combine data from studies, respectively. Potential publication bias was evaluated by Egger's test. Sensitivity analysis was also performed to evaluate the stability and reliability in results. Results: Decreased susceptibility of LC was found in all genetic models contrast in Bsm1 gene of VDR (a vs. A: OR = 0.62, 95 % CI = 0.44-0.87; aa vs. AA: OR = 0.76, 95 % CI = 0.60-0.96; Aa vs. AA: OR = 0.59, 95 % CI = 0.39-0.88; aa vs. AA+Aa: OR = 0.80, 95 % CI = 0.64-0.99; Aa+aa vs. AA: OR = 0.57, 95 % CI = 0.37-0.86). The similar results were also found in partial genetic models of Taq1 (a vs. A: OR = 0.88, 95 % CI = 0.79-0.98; aa vs. AA+Aa: OR = 0.84, 95 % CI = 0.73-0.98) and Cdx-2 (Aa vs. AA: OR = 0.80, 95 % CI = 0.66-0.98; Aa+aa vs. AA: OR = 0.79, 95 % CI = 0.65-0.96). Likewise, significant correlation between Bsm1, Taq1 polymorphism and LC risk was detected among Asians. Cdx-2 polymorphism was considered as a protective factor in Caucasians, whereas no association of Apal polymorphism with LC risk was observed in Asians and Caucasians for all genetic models. Conclusion: The results of this meta-analysis suggested that Bsm1, Taq1 and Cdx-2 polymorphism may contribute to lung cancer susceptibility, more studies need be conducted to confirm in the future.
format Online
Article
Text
id pubmed-6636285
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-66362852019-07-22 Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis Li, Meng Liu, Xinyu Liu, Na Yang, Tian Shi, Puyu He, Ruiqing Chen, Mingwei J Cancer Research Paper Purpose: The aim of this meta-analysis was to investigate polymorphism of Bsm1, Apal, Taq1 and Cdx-2 in vitamin D receptor (VDR) associations in relation to lung cancer (LC) susceptibility. Methods: 9 literatures were recruited into this meta-analysis from PubMed, PMC, Embase, Web of Science, Cochrane library and CNKI. STATA version 15.1 was used for statistical tests. The heterogeneity was tested using I(2) statistics. According to the value of I(2), the random-effect model (REM) or fixed-effect model (FEM) was selected to combine data from studies, respectively. Potential publication bias was evaluated by Egger's test. Sensitivity analysis was also performed to evaluate the stability and reliability in results. Results: Decreased susceptibility of LC was found in all genetic models contrast in Bsm1 gene of VDR (a vs. A: OR = 0.62, 95 % CI = 0.44-0.87; aa vs. AA: OR = 0.76, 95 % CI = 0.60-0.96; Aa vs. AA: OR = 0.59, 95 % CI = 0.39-0.88; aa vs. AA+Aa: OR = 0.80, 95 % CI = 0.64-0.99; Aa+aa vs. AA: OR = 0.57, 95 % CI = 0.37-0.86). The similar results were also found in partial genetic models of Taq1 (a vs. A: OR = 0.88, 95 % CI = 0.79-0.98; aa vs. AA+Aa: OR = 0.84, 95 % CI = 0.73-0.98) and Cdx-2 (Aa vs. AA: OR = 0.80, 95 % CI = 0.66-0.98; Aa+aa vs. AA: OR = 0.79, 95 % CI = 0.65-0.96). Likewise, significant correlation between Bsm1, Taq1 polymorphism and LC risk was detected among Asians. Cdx-2 polymorphism was considered as a protective factor in Caucasians, whereas no association of Apal polymorphism with LC risk was observed in Asians and Caucasians for all genetic models. Conclusion: The results of this meta-analysis suggested that Bsm1, Taq1 and Cdx-2 polymorphism may contribute to lung cancer susceptibility, more studies need be conducted to confirm in the future. Ivyspring International Publisher 2019-06-09 /pmc/articles/PMC6636285/ /pubmed/31333781 http://dx.doi.org/10.7150/jca.33431 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Li, Meng
Liu, Xinyu
Liu, Na
Yang, Tian
Shi, Puyu
He, Ruiqing
Chen, Mingwei
Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
title Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
title_full Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
title_fullStr Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
title_full_unstemmed Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
title_short Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
title_sort association between polymorphisms of vitamin d receptor and lung cancer susceptibility: evidence from an updated meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636285/
https://www.ncbi.nlm.nih.gov/pubmed/31333781
http://dx.doi.org/10.7150/jca.33431
work_keys_str_mv AT limeng associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis
AT liuxinyu associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis
AT liuna associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis
AT yangtian associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis
AT shipuyu associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis
AT heruiqing associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis
AT chenmingwei associationbetweenpolymorphismsofvitamindreceptorandlungcancersusceptibilityevidencefromanupdatedmetaanalysis