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Metabolic Reprogramming Promotes Myogenesis During Aging

Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during agin...

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Autores principales: Belli, Roberta, Bonato, Agnese, De Angelis, Luciana, Mirabilii, Simone, Ricciardi, Maria Rosaria, Tafuri, Agostino, Molfino, Alessio, Gorini, Stefania, Leigheb, Massimiliano, Costelli, Paola, Caruso, Maurizia, Muscaritoli, Maurizio, Ferraro, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636331/
https://www.ncbi.nlm.nih.gov/pubmed/31354530
http://dx.doi.org/10.3389/fphys.2019.00897
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author Belli, Roberta
Bonato, Agnese
De Angelis, Luciana
Mirabilii, Simone
Ricciardi, Maria Rosaria
Tafuri, Agostino
Molfino, Alessio
Gorini, Stefania
Leigheb, Massimiliano
Costelli, Paola
Caruso, Maurizia
Muscaritoli, Maurizio
Ferraro, Elisabetta
author_facet Belli, Roberta
Bonato, Agnese
De Angelis, Luciana
Mirabilii, Simone
Ricciardi, Maria Rosaria
Tafuri, Agostino
Molfino, Alessio
Gorini, Stefania
Leigheb, Massimiliano
Costelli, Paola
Caruso, Maurizia
Muscaritoli, Maurizio
Ferraro, Elisabetta
author_sort Belli, Roberta
collection PubMed
description Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia.
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spelling pubmed-66363312019-07-26 Metabolic Reprogramming Promotes Myogenesis During Aging Belli, Roberta Bonato, Agnese De Angelis, Luciana Mirabilii, Simone Ricciardi, Maria Rosaria Tafuri, Agostino Molfino, Alessio Gorini, Stefania Leigheb, Massimiliano Costelli, Paola Caruso, Maurizia Muscaritoli, Maurizio Ferraro, Elisabetta Front Physiol Physiology Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia. Frontiers Media S.A. 2019-07-10 /pmc/articles/PMC6636331/ /pubmed/31354530 http://dx.doi.org/10.3389/fphys.2019.00897 Text en Copyright © 2019 Belli, Bonato, De Angelis, Mirabilii, Ricciardi, Tafuri, Molfino, Gorini, Leigheb, Costelli, Caruso, Muscaritoli and Ferraro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Belli, Roberta
Bonato, Agnese
De Angelis, Luciana
Mirabilii, Simone
Ricciardi, Maria Rosaria
Tafuri, Agostino
Molfino, Alessio
Gorini, Stefania
Leigheb, Massimiliano
Costelli, Paola
Caruso, Maurizia
Muscaritoli, Maurizio
Ferraro, Elisabetta
Metabolic Reprogramming Promotes Myogenesis During Aging
title Metabolic Reprogramming Promotes Myogenesis During Aging
title_full Metabolic Reprogramming Promotes Myogenesis During Aging
title_fullStr Metabolic Reprogramming Promotes Myogenesis During Aging
title_full_unstemmed Metabolic Reprogramming Promotes Myogenesis During Aging
title_short Metabolic Reprogramming Promotes Myogenesis During Aging
title_sort metabolic reprogramming promotes myogenesis during aging
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636331/
https://www.ncbi.nlm.nih.gov/pubmed/31354530
http://dx.doi.org/10.3389/fphys.2019.00897
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