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Metabolic Reprogramming Promotes Myogenesis During Aging
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during agin...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636331/ https://www.ncbi.nlm.nih.gov/pubmed/31354530 http://dx.doi.org/10.3389/fphys.2019.00897 |
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author | Belli, Roberta Bonato, Agnese De Angelis, Luciana Mirabilii, Simone Ricciardi, Maria Rosaria Tafuri, Agostino Molfino, Alessio Gorini, Stefania Leigheb, Massimiliano Costelli, Paola Caruso, Maurizia Muscaritoli, Maurizio Ferraro, Elisabetta |
author_facet | Belli, Roberta Bonato, Agnese De Angelis, Luciana Mirabilii, Simone Ricciardi, Maria Rosaria Tafuri, Agostino Molfino, Alessio Gorini, Stefania Leigheb, Massimiliano Costelli, Paola Caruso, Maurizia Muscaritoli, Maurizio Ferraro, Elisabetta |
author_sort | Belli, Roberta |
collection | PubMed |
description | Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia. |
format | Online Article Text |
id | pubmed-6636331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66363312019-07-26 Metabolic Reprogramming Promotes Myogenesis During Aging Belli, Roberta Bonato, Agnese De Angelis, Luciana Mirabilii, Simone Ricciardi, Maria Rosaria Tafuri, Agostino Molfino, Alessio Gorini, Stefania Leigheb, Massimiliano Costelli, Paola Caruso, Maurizia Muscaritoli, Maurizio Ferraro, Elisabetta Front Physiol Physiology Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia. Frontiers Media S.A. 2019-07-10 /pmc/articles/PMC6636331/ /pubmed/31354530 http://dx.doi.org/10.3389/fphys.2019.00897 Text en Copyright © 2019 Belli, Bonato, De Angelis, Mirabilii, Ricciardi, Tafuri, Molfino, Gorini, Leigheb, Costelli, Caruso, Muscaritoli and Ferraro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Belli, Roberta Bonato, Agnese De Angelis, Luciana Mirabilii, Simone Ricciardi, Maria Rosaria Tafuri, Agostino Molfino, Alessio Gorini, Stefania Leigheb, Massimiliano Costelli, Paola Caruso, Maurizia Muscaritoli, Maurizio Ferraro, Elisabetta Metabolic Reprogramming Promotes Myogenesis During Aging |
title | Metabolic Reprogramming Promotes Myogenesis During Aging |
title_full | Metabolic Reprogramming Promotes Myogenesis During Aging |
title_fullStr | Metabolic Reprogramming Promotes Myogenesis During Aging |
title_full_unstemmed | Metabolic Reprogramming Promotes Myogenesis During Aging |
title_short | Metabolic Reprogramming Promotes Myogenesis During Aging |
title_sort | metabolic reprogramming promotes myogenesis during aging |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636331/ https://www.ncbi.nlm.nih.gov/pubmed/31354530 http://dx.doi.org/10.3389/fphys.2019.00897 |
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