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The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636478/ https://www.ncbi.nlm.nih.gov/pubmed/31354843 http://dx.doi.org/10.1155/2019/1273235 |
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author | Kaguthi, Grace Nduba, Videlis Murithi, Wilfred Verver, Suzanne |
author_facet | Kaguthi, Grace Nduba, Videlis Murithi, Wilfred Verver, Suzanne |
author_sort | Kaguthi, Grace |
collection | PubMed |
description | There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya. A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence. TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography. The American Thoracic Society Criteria (ATS) were applied to identify NTM disease. Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated. NTM were isolated from 19/742 (2.6%) infants. M. fortuitum was most frequently speciated (32%). Total person-time was 3330 years. NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7). Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0). None of the infants with NTM isolated met the criteria for NTM disease. The incidence of NTM isolation was comparable to similar studies in Africa. NTM isolation did not meet ATS criteria for disease and could represent colonisation. TB disease appears to be structural lung disease predisposing to NTM colonisation. |
format | Online Article Text |
id | pubmed-6636478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66364782019-07-28 The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya Kaguthi, Grace Nduba, Videlis Murithi, Wilfred Verver, Suzanne J Trop Med Research Article There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya. A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence. TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography. The American Thoracic Society Criteria (ATS) were applied to identify NTM disease. Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated. NTM were isolated from 19/742 (2.6%) infants. M. fortuitum was most frequently speciated (32%). Total person-time was 3330 years. NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7). Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0). None of the infants with NTM isolated met the criteria for NTM disease. The incidence of NTM isolation was comparable to similar studies in Africa. NTM isolation did not meet ATS criteria for disease and could represent colonisation. TB disease appears to be structural lung disease predisposing to NTM colonisation. Hindawi 2019-07-03 /pmc/articles/PMC6636478/ /pubmed/31354843 http://dx.doi.org/10.1155/2019/1273235 Text en Copyright © 2019 Grace Kaguthi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kaguthi, Grace Nduba, Videlis Murithi, Wilfred Verver, Suzanne The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title | The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_full | The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_fullStr | The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_full_unstemmed | The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_short | The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_sort | incidence of non-tuberculous mycobacteria in infants in kenya |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636478/ https://www.ncbi.nlm.nih.gov/pubmed/31354843 http://dx.doi.org/10.1155/2019/1273235 |
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