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The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya

There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB...

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Autores principales: Kaguthi, Grace, Nduba, Videlis, Murithi, Wilfred, Verver, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636478/
https://www.ncbi.nlm.nih.gov/pubmed/31354843
http://dx.doi.org/10.1155/2019/1273235
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author Kaguthi, Grace
Nduba, Videlis
Murithi, Wilfred
Verver, Suzanne
author_facet Kaguthi, Grace
Nduba, Videlis
Murithi, Wilfred
Verver, Suzanne
author_sort Kaguthi, Grace
collection PubMed
description There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya. A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence. TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography. The American Thoracic Society Criteria (ATS) were applied to identify NTM disease. Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated. NTM were isolated from 19/742 (2.6%) infants. M. fortuitum was most frequently speciated (32%). Total person-time was 3330 years. NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7). Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0). None of the infants with NTM isolated met the criteria for NTM disease. The incidence of NTM isolation was comparable to similar studies in Africa. NTM isolation did not meet ATS criteria for disease and could represent colonisation. TB disease appears to be structural lung disease predisposing to NTM colonisation.
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spelling pubmed-66364782019-07-28 The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya Kaguthi, Grace Nduba, Videlis Murithi, Wilfred Verver, Suzanne J Trop Med Research Article There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya. A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence. TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography. The American Thoracic Society Criteria (ATS) were applied to identify NTM disease. Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated. NTM were isolated from 19/742 (2.6%) infants. M. fortuitum was most frequently speciated (32%). Total person-time was 3330 years. NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7). Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0). None of the infants with NTM isolated met the criteria for NTM disease. The incidence of NTM isolation was comparable to similar studies in Africa. NTM isolation did not meet ATS criteria for disease and could represent colonisation. TB disease appears to be structural lung disease predisposing to NTM colonisation. Hindawi 2019-07-03 /pmc/articles/PMC6636478/ /pubmed/31354843 http://dx.doi.org/10.1155/2019/1273235 Text en Copyright © 2019 Grace Kaguthi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kaguthi, Grace
Nduba, Videlis
Murithi, Wilfred
Verver, Suzanne
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
title The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
title_full The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
title_fullStr The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
title_full_unstemmed The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
title_short The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
title_sort incidence of non-tuberculous mycobacteria in infants in kenya
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636478/
https://www.ncbi.nlm.nih.gov/pubmed/31354843
http://dx.doi.org/10.1155/2019/1273235
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