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Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)

The association of latent toxoplasmosis with mental disorders in general and with schizophrenia in particular was noticed in the mid-1950s. In subsequent years, the role of Toxoplasma gondii was established based on its ability to survive for long periods of time in the nerve cells of the brain. The...

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Autores principales: Stepanova, Ekaterina V., Kondrashin, Anatoly V., Sergiev, Vladimir P., Morozova, Lola F., Turbabina, Natalia A., Maksimova, Maria S., Romanov, Dmitry V., Kinkulkina, Marina A., Lazareva, Alena V., Morozov, Evgeny N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636601/
https://www.ncbi.nlm.nih.gov/pubmed/31291336
http://dx.doi.org/10.1371/journal.pone.0219454
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author Stepanova, Ekaterina V.
Kondrashin, Anatoly V.
Sergiev, Vladimir P.
Morozova, Lola F.
Turbabina, Natalia A.
Maksimova, Maria S.
Romanov, Dmitry V.
Kinkulkina, Marina A.
Lazareva, Alena V.
Morozov, Evgeny N.
author_facet Stepanova, Ekaterina V.
Kondrashin, Anatoly V.
Sergiev, Vladimir P.
Morozova, Lola F.
Turbabina, Natalia A.
Maksimova, Maria S.
Romanov, Dmitry V.
Kinkulkina, Marina A.
Lazareva, Alena V.
Morozov, Evgeny N.
author_sort Stepanova, Ekaterina V.
collection PubMed
description The association of latent toxoplasmosis with mental disorders in general and with schizophrenia in particular was noticed in the mid-1950s. In subsequent years, the role of Toxoplasma gondii was established based on its ability to survive for long periods of time in the nerve cells of the brain. The acute manifestations of the infection include psychopathic symptoms resembling those of schizophrenia. In the former USSR, and in other parts of the world, a number of studies were performed with respect to the association of latent toxoplasmosis and schizophrenia. However, with the dissolution of the USSR at the beginning of the 1990s, studies on the subject were halted due to financial problems and have resumed only recently. The reasons for the resumption of such studies in contemporary Russia are related to the progressively increasing incidence of schizophrenia over the last 25–30 years in the country. According to official data, approximately 550 000 persons reported suffering from the disease in 2014. There are reasons to believe that this is only a fraction of the real burden of the disease. Economically, it cost the state no less than approximately US $10 billion. The purpose of the study was to identify the level of toxoplasmosis seroprevalence in patients with verified diagnoses of schizophrenia in comparison to healthy people in Moscow City and in the Moscow region. A total of 155 persons constituted the patients group and 152 healthy people were in the control group. An integrated approach to the diagnosis and comparison of data from the entire spectrum of serological markers of infection was used, including the detection of specific IgM and the determination of IgG concentrations. It was found that among persons with neuropsychiatric disorders, the incidence of cases with latent toxoplasmosis was higher than in the control group. The effect of toxoplasmosis was significant and similar for men and women. Further statistical analyses revealed that among patients with a diagnosis of schizophrenia, the incidence of latent toxoplasmosis was significantly higher than in the control group. These data are in agreement with the results of similar studies in other countries.
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spelling pubmed-66366012019-07-25 Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia) Stepanova, Ekaterina V. Kondrashin, Anatoly V. Sergiev, Vladimir P. Morozova, Lola F. Turbabina, Natalia A. Maksimova, Maria S. Romanov, Dmitry V. Kinkulkina, Marina A. Lazareva, Alena V. Morozov, Evgeny N. PLoS One Research Article The association of latent toxoplasmosis with mental disorders in general and with schizophrenia in particular was noticed in the mid-1950s. In subsequent years, the role of Toxoplasma gondii was established based on its ability to survive for long periods of time in the nerve cells of the brain. The acute manifestations of the infection include psychopathic symptoms resembling those of schizophrenia. In the former USSR, and in other parts of the world, a number of studies were performed with respect to the association of latent toxoplasmosis and schizophrenia. However, with the dissolution of the USSR at the beginning of the 1990s, studies on the subject were halted due to financial problems and have resumed only recently. The reasons for the resumption of such studies in contemporary Russia are related to the progressively increasing incidence of schizophrenia over the last 25–30 years in the country. According to official data, approximately 550 000 persons reported suffering from the disease in 2014. There are reasons to believe that this is only a fraction of the real burden of the disease. Economically, it cost the state no less than approximately US $10 billion. The purpose of the study was to identify the level of toxoplasmosis seroprevalence in patients with verified diagnoses of schizophrenia in comparison to healthy people in Moscow City and in the Moscow region. A total of 155 persons constituted the patients group and 152 healthy people were in the control group. An integrated approach to the diagnosis and comparison of data from the entire spectrum of serological markers of infection was used, including the detection of specific IgM and the determination of IgG concentrations. It was found that among persons with neuropsychiatric disorders, the incidence of cases with latent toxoplasmosis was higher than in the control group. The effect of toxoplasmosis was significant and similar for men and women. Further statistical analyses revealed that among patients with a diagnosis of schizophrenia, the incidence of latent toxoplasmosis was significantly higher than in the control group. These data are in agreement with the results of similar studies in other countries. Public Library of Science 2019-07-10 /pmc/articles/PMC6636601/ /pubmed/31291336 http://dx.doi.org/10.1371/journal.pone.0219454 Text en © 2019 Stepanova et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Stepanova, Ekaterina V.
Kondrashin, Anatoly V.
Sergiev, Vladimir P.
Morozova, Lola F.
Turbabina, Natalia A.
Maksimova, Maria S.
Romanov, Dmitry V.
Kinkulkina, Marina A.
Lazareva, Alena V.
Morozov, Evgeny N.
Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
title Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
title_full Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
title_fullStr Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
title_full_unstemmed Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
title_short Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
title_sort toxoplasmosis and mental disorders in the russian federation (with special reference to schizophrenia)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636601/
https://www.ncbi.nlm.nih.gov/pubmed/31291336
http://dx.doi.org/10.1371/journal.pone.0219454
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