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The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal
Purpose: To evaluate ocular physiological responses to etafilcon A multifocal (etMF) daily disposable (DD) lenses after 4 weeks of wear, when switching from habitual silicone hydrogel (SiHy) daily wear. Method: A single-arm, open-label, bilateral dispensing study was conducted in 39 habitual spheric...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636608/ https://www.ncbi.nlm.nih.gov/pubmed/31371916 http://dx.doi.org/10.2147/OPTH.S208905 |
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author | Moezzi, Amir M Varikooty, Jalaiah Luensmann, Doerte Schulze, Marc-Matthias Ng, Alison Karkkainen, Thomas Xu, Jing Jones, Lyndon |
author_facet | Moezzi, Amir M Varikooty, Jalaiah Luensmann, Doerte Schulze, Marc-Matthias Ng, Alison Karkkainen, Thomas Xu, Jing Jones, Lyndon |
author_sort | Moezzi, Amir M |
collection | PubMed |
description | Purpose: To evaluate ocular physiological responses to etafilcon A multifocal (etMF) daily disposable (DD) lenses after 4 weeks of wear, when switching from habitual silicone hydrogel (SiHy) daily wear. Method: A single-arm, open-label, bilateral dispensing study was conducted in 39 habitual spherical SiHy wearers (14 hyperopes; 25 myopes). Clinical visits occurred with habitual SiHy (control) at baseline and after 4 weeks of etMF DD open-eye lens wear at exit. Objective limbal/bulbar hyperemia using the Oculus K5M (0–4) and subjective grading of lid wiper epitheliopathy (LWE) (0–4) were tested for non-inferiority (NI), using a margin of 1 grade. Corneal thickness along a 10 mm cord was measured using the Visante OCT and tested for NI using a 30 μm margin. Corneal staining area was graded (0–100%). Results: The least-square mean differences (LSMD) and 95% confidence interval (95% CI) between etMF DD and habitual SiHy in central and peripheral corneal thickness (μm) were 3.64 (−2.0, 9.29) and 3.0 (−7.72, 13.72) in hyperopic, and 3.56 (−0.66, 7.78) and 6.40 (−1.62, 14.42) in myopic subjects. The LSMD (95% CI) for bulbar and limbal hyperemia were −0.08 (−0.19, 0.02) and −0.01 (−0.12, 0.09) in hyperopes, and 0.04 (−0.03, 0.12) and 0.04 (−0.04, 0.11) in myopes. The LSMD (95% CI) for LWE were 0.11 (−0.39, 0.60) and 0.30 (−0.07, 0.67) for hyperopes and myopes, respectively. Conclusions: No clinically significant differences in a variety of physiological responses were found when habitual reusable SiHy daily wear subjects were refitted into hydrogel etMF, when the subjects were followed for 4 weeks. |
format | Online Article Text |
id | pubmed-6636608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-66366082019-08-01 The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal Moezzi, Amir M Varikooty, Jalaiah Luensmann, Doerte Schulze, Marc-Matthias Ng, Alison Karkkainen, Thomas Xu, Jing Jones, Lyndon Clin Ophthalmol Original Research Purpose: To evaluate ocular physiological responses to etafilcon A multifocal (etMF) daily disposable (DD) lenses after 4 weeks of wear, when switching from habitual silicone hydrogel (SiHy) daily wear. Method: A single-arm, open-label, bilateral dispensing study was conducted in 39 habitual spherical SiHy wearers (14 hyperopes; 25 myopes). Clinical visits occurred with habitual SiHy (control) at baseline and after 4 weeks of etMF DD open-eye lens wear at exit. Objective limbal/bulbar hyperemia using the Oculus K5M (0–4) and subjective grading of lid wiper epitheliopathy (LWE) (0–4) were tested for non-inferiority (NI), using a margin of 1 grade. Corneal thickness along a 10 mm cord was measured using the Visante OCT and tested for NI using a 30 μm margin. Corneal staining area was graded (0–100%). Results: The least-square mean differences (LSMD) and 95% confidence interval (95% CI) between etMF DD and habitual SiHy in central and peripheral corneal thickness (μm) were 3.64 (−2.0, 9.29) and 3.0 (−7.72, 13.72) in hyperopic, and 3.56 (−0.66, 7.78) and 6.40 (−1.62, 14.42) in myopic subjects. The LSMD (95% CI) for bulbar and limbal hyperemia were −0.08 (−0.19, 0.02) and −0.01 (−0.12, 0.09) in hyperopes, and 0.04 (−0.03, 0.12) and 0.04 (−0.04, 0.11) in myopes. The LSMD (95% CI) for LWE were 0.11 (−0.39, 0.60) and 0.30 (−0.07, 0.67) for hyperopes and myopes, respectively. Conclusions: No clinically significant differences in a variety of physiological responses were found when habitual reusable SiHy daily wear subjects were refitted into hydrogel etMF, when the subjects were followed for 4 weeks. Dove 2019-07-10 /pmc/articles/PMC6636608/ /pubmed/31371916 http://dx.doi.org/10.2147/OPTH.S208905 Text en © 2019 Moezzi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Moezzi, Amir M Varikooty, Jalaiah Luensmann, Doerte Schulze, Marc-Matthias Ng, Alison Karkkainen, Thomas Xu, Jing Jones, Lyndon The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
title | The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
title_full | The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
title_fullStr | The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
title_full_unstemmed | The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
title_short | The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
title_sort | short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636608/ https://www.ncbi.nlm.nih.gov/pubmed/31371916 http://dx.doi.org/10.2147/OPTH.S208905 |
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