Cargando…

Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays

In the past few years, several types of artificial transcriptional activator, based on CRISPR-Cas9, have been developed and refined. Of these, in synergistic activation mediator and SunTag systems, the effector proteins, expressed in trans, can be recruited to the target sites via the MS2 RNA-bindin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kunii, Atsushi, Hara, Yoshihiro, Takenaga, Mitsumasa, Hattori, Naoko, Fukazawa, Takuya, Ushijima, Toshikazu, Yamamoto, Takashi, Sakuma, Tetsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636879/ https://www.ncbi.nlm.nih.gov/pubmed/31021277 http://dx.doi.org/10.1089/crispr.2018.0009

Ejemplares similares

Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma
por: Yoshida, Masakazu, et al.
Publicado: (2018)

Homologous Recombination-Independent Large Gene Cassette Knock-in in CHO Cells Using TALEN and MMEJ-Directed Donor Plasmids
por: Sakuma, Tetsushi, et al.
Publicado: (2015)

Biased genome editing using the local accumulation of DSB repair molecules system
por: Nakade, Shota, et al.
Publicado: (2018)

Establishment of expanded and streamlined pipeline of PITCh knock-in – a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO
por: Nakamae, Kazuki, et al.
Publicado: (2017)

Epigenetic impact of infection on carcinogenesis: mechanisms and applications
por: Hattori, Naoko, et al.
Publicado: (2016)

Accumulation of genetic and epigenetic alterations in normal cells and cancer risk
por: Takeshima, Hideyuki, et al.
Publicado: (2019)

Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells
por: Hattori, Naoko, et al.
Publicado: (2013)

A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy
por: Ueda, Sho, et al.
Publicado: (2022)

Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level
por: Takeshima, Hideyuki, et al.
Publicado: (2020)

P1233: TUMOR PREVENTION USING DNA DEMETHYLATING AGENTS ON VIRUS-DERIVED CARCINOGENESIS IN MICE.
por: Yamamoto, Yuta, et al.
Publicado: (2023)

Novel prodrugs of decitabine with greater metabolic stability and less toxicity
por: Hattori, Naoko, et al.
Publicado: (2019)

Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects
por: Ureshino, Hiroshi, et al.
Publicado: (2021)

Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice
por: Korenaga, Masaaki, et al.
Publicado: (2015)

Acceleration of cancer science with genome editing and related technologies
por: Sakuma, Tetsushi, et al.
Publicado: (2018)

Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL
por: Kurahashi, Yuki, et al.
Publicado: (2022)

Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes
por: Nakagawa, Yoshiko, et al.
Publicado: (2015)

Charge tagged semileptonic branching fractions in $\bar{B}$ and $B^{+}$ decays
por: Feindt, Michael, et al.
Publicado: (1998)

Measurement of the Z branching fraction into bottom quarks using lifetime tags
por: Easo, S
Publicado: (1998)

Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model
por: Hattori, Naoko, et al.
Publicado: (2018)

A High Excision Potential of TALENs for Integrated DNA of HIV-Based Lentiviral Vector
por: Ebina, Hirotaka, et al.
Publicado: (2015)

Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19
por: Norinder, Ulf, et al.
Publicado: (2020)

Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
por: Shioi, Yoshihiro, et al.
Publicado: (2021)

Estimation of the Fraction of Cancer Cells in a Tumor DNA Sample Using DNA Methylation
por: Takahashi, Takamasa, et al.
Publicado: (2013)

Epigenetic field for cancerization: its cause and clinical implications
por: Ushijima, Toshikazu
Publicado: (2013)

Cas9, Cpf1 and C2c1/2/3―What's next?
por: Nakade, Shota, et al.
Publicado: (2017)

Measurement of the Z ^0-> b\barb branching ratio by hemisphere double tagging
por: DELPHI Collaboration
Publicado: (2018)

PATL: A RFID Tag Localization based on Phased Array Antenna
por: Qiu, Lanxin, et al.
Publicado: (2017)

Use of retrograde left subclavian branch portal of Gore TAG thoracic branch endoprosthesis for physician-modified fenestrated branched endovascular repair of thoracoabdominal aortic aneurysm
por: DiBartolomeo, Alexander D., et al.
Publicado: (2023)

Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy
por: Tochio, Naoya, et al.
Publicado: (2016)

Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis
por: Nakazato, Hidetsugu, et al.
Publicado: (2016)

Measurements of partial branching fractions of inclusive B→Xuℓ+νℓ decays with hadronic tagging
por: Cao, L., et al.
Publicado: (2021)

Superior triacylglycerol (TAG) accumulation in starchless mutants of Scenedesmus obliquus: (II) evaluation of TAG yield and productivity in controlled photobioreactors
por: Breuer, Guido, et al.
Publicado: (2014)

Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas
por: Takeuchi, Tomomi, et al.
Publicado: (2019)

Accelerating covering array generation by combinatorial join for industry scale software testing
por: Ukai, Hiroshi, et al.
Publicado: (2022)

Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples
por: Nishiyama, Kazuhiro, et al.
Publicado: (2023)

Simple knockout by electroporation of engineered endonucleases into intact rat embryos
por: Kaneko, Takehito, et al.
Publicado: (2014)

Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells
por: Ochiai, Hiroshi, et al.
Publicado: (2014)

Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease
por: Matsuzaki, Yuriko, et al.
Publicado: (2017)

Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology
por: Shimode, Sayumi, et al.
Publicado: (2022)

Heteroaryliodonium(III) Salts as Highly Reactive Electrophiles
por: Takenaga, Naoko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jqovltmvf377s29bn6qo12a82o