Single-Step, High-Efficiency CRISPR-Cas9 Genome Editing in Primary Human Disease-Derived Fibroblasts

Genome editing is a tool that has many applications, including the validation of potential drug targets. However, performing genome editing in low-passage primary human cells with the greatest physiological relevance is notoriously difficult. High editing efficiency is desired because it enables gen...

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Detalles Bibliográficos
Autores principales: Martufi, Matteo, Good, Robert B., Rapiteanu, Radu, Schmidt, Tobias, Patili, Eleni, Tvermosegaard, Ketil, New, Maria, Nanthakumar, Carmel B., Betts, Joanna, Blanchard, Andy D., Maratou, Klio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636881/
https://www.ncbi.nlm.nih.gov/pubmed/31021235
http://dx.doi.org/10.1089/crispr.2018.0047

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