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MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report
RATIONALE: Ameloblastoma is generally characterized as a benign tumor originating in odontogenic epithelium. However, few cases of metastatic malignant ameloblastoma have also been reported. Due to the low incidence of malignant ameloblastoma, there is no established treatment regimen. To explore ef...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636961/ https://www.ncbi.nlm.nih.gov/pubmed/31232921 http://dx.doi.org/10.1097/MD.0000000000015873 |
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author | Li, Danyang Xu, Shuning Sun, Miaomiao Qiao, Lei Wang, Lifeng Liu, Ying |
author_facet | Li, Danyang Xu, Shuning Sun, Miaomiao Qiao, Lei Wang, Lifeng Liu, Ying |
author_sort | Li, Danyang |
collection | PubMed |
description | RATIONALE: Ameloblastoma is generally characterized as a benign tumor originating in odontogenic epithelium. However, few cases of metastatic malignant ameloblastoma have also been reported. Due to the low incidence of malignant ameloblastoma, there is no established treatment regimen. To explore effective treatment for malignant ameloblastoma, we reported this case study. PATIENTS CONCERNS: This report described a case of a 28-year-old malignant ameloblastoma female patient with multiple metastasis (brain and lung). DIAGNOSES: The patient presented ameloblastoma of the left mandible in 2012. Three years later, local recurrence and brain metastasis was observed during a follow-up examination. Five years later, malignant ameloblastoma was detected by imaging and immunohistochemistry in the bilateral multiple pulmonary nodules and mediastinal lymph nodes. INTERVENTIONS: The patient was initially treated with tumor resection. Three years later after local recurrence and brain metastasis, she was accepted the extensive mandibulectomy supplemented with brain stereotactic body radiotherapy (SBRT). When diagnosed with pulmonary metastasis, the patient received combined chemotherapy regimen of MAID (mesna, adriamycin, ifosfamide and dacarbazine) for 6 cycles. OUTCOMES: The efficacy evaluation was partial remission (PR) after the 6 cycles of MAID. The last patient follow-up was July 24th 2018, and no evidence of progression was observed. The progression-free survival (PFS) of the patient was more than 9 months. LESSONS: Surgical resection is the optimal treatment for locally recurrent ameloblastoma. SBRT may be an effective treatment for unresectable oligometastasis of malignant ameloblastoma. Finally, combined chemotherapy of MAID showed encouraging effects in the management of metastatic malignant ameloblastoma. |
format | Online Article Text |
id | pubmed-6636961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-66369612019-08-01 MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report Li, Danyang Xu, Shuning Sun, Miaomiao Qiao, Lei Wang, Lifeng Liu, Ying Medicine (Baltimore) Research Article RATIONALE: Ameloblastoma is generally characterized as a benign tumor originating in odontogenic epithelium. However, few cases of metastatic malignant ameloblastoma have also been reported. Due to the low incidence of malignant ameloblastoma, there is no established treatment regimen. To explore effective treatment for malignant ameloblastoma, we reported this case study. PATIENTS CONCERNS: This report described a case of a 28-year-old malignant ameloblastoma female patient with multiple metastasis (brain and lung). DIAGNOSES: The patient presented ameloblastoma of the left mandible in 2012. Three years later, local recurrence and brain metastasis was observed during a follow-up examination. Five years later, malignant ameloblastoma was detected by imaging and immunohistochemistry in the bilateral multiple pulmonary nodules and mediastinal lymph nodes. INTERVENTIONS: The patient was initially treated with tumor resection. Three years later after local recurrence and brain metastasis, she was accepted the extensive mandibulectomy supplemented with brain stereotactic body radiotherapy (SBRT). When diagnosed with pulmonary metastasis, the patient received combined chemotherapy regimen of MAID (mesna, adriamycin, ifosfamide and dacarbazine) for 6 cycles. OUTCOMES: The efficacy evaluation was partial remission (PR) after the 6 cycles of MAID. The last patient follow-up was July 24th 2018, and no evidence of progression was observed. The progression-free survival (PFS) of the patient was more than 9 months. LESSONS: Surgical resection is the optimal treatment for locally recurrent ameloblastoma. SBRT may be an effective treatment for unresectable oligometastasis of malignant ameloblastoma. Finally, combined chemotherapy of MAID showed encouraging effects in the management of metastatic malignant ameloblastoma. Wolters Kluwer Health 2019-06-21 /pmc/articles/PMC6636961/ /pubmed/31232921 http://dx.doi.org/10.1097/MD.0000000000015873 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Li, Danyang Xu, Shuning Sun, Miaomiao Qiao, Lei Wang, Lifeng Liu, Ying MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report |
title | MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report |
title_full | MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report |
title_fullStr | MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report |
title_full_unstemmed | MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report |
title_short | MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report |
title_sort | maid chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: a case report |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636961/ https://www.ncbi.nlm.nih.gov/pubmed/31232921 http://dx.doi.org/10.1097/MD.0000000000015873 |
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