The regulatory B cell–mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity

The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)–producing regulatory B (IL-10(+) B(reg)) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10(+) B(r...

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Detalles Bibliográficos
Autores principales: Kim, Hyuk Soon, Lee, Min Bum, Lee, Dajeong, Min, Keun Young, Koo, Jimo, Kim, Hyun Woo, Park, Young Hwan, Kim, Su Jeong, Ikutani, Masashi, Takaki, Satoshi, Kim, Young Mi, Choi, Wahn Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636983/
https://www.ncbi.nlm.nih.gov/pubmed/31328158
http://dx.doi.org/10.1126/sciadv.aav8152
Descripción
Sumario:The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)–producing regulatory B (IL-10(+) B(reg)) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10(+) B(reg) cells are generated and maintained is still very limited. Here, we found that IL-10(+) B(reg) cells suppress the activation of IL-13–producing type 2 innate lymphoid cells (IL-13(+) ILC2s) in an IL-10–dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10(+) B(reg) cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10(+) B(reg) cells, and IL-13(+) ILC2s in CHS.

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