Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss

Aminoglycoside antibiotics are essential for treating life-threatening bacterial infections, despite the risk of lifelong hearing loss. Infections induce inflammation and up-regulate expression of candidate aminoglycoside-permeant cation channels, including transient receptor potential vanilloid-1 (...

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Detalles Bibliográficos
Autores principales: Jiang, Meiyan, Li, Hongzhe, Johnson, Anastasiya, Karasawa, Takatoshi, Zhang, Yuan, Meier, William B., Taghizadeh, Farshid, Kachelmeier, Allan, Steyger, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636990/
https://www.ncbi.nlm.nih.gov/pubmed/31328162
http://dx.doi.org/10.1126/sciadv.aaw1836

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