Ca(2+) signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats

BACKGROUND AND PURPOSE: Celastrol exhibits anti‐arthritic effects in rheumatoid arthritis (RA), but the role of celastrol‐mediated Ca(2+) mobilization in treatment of RA remains undefined. Here, we describe a regulatory role for celastrol‐induced Ca(2+) signalling in synovial fibroblasts of RA patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Vincent Kam Wai, Qiu, Congling, Xu, Su‐Wei, Law, Betty Yuen Kwan, Zeng, Wu, Wang, Hui, Michelangeli, Francesco, Dias, Ivo Ricardo De Seabra Rodrigues, Qu, Yuan Qing, Chan, Tsz Wai, Han, Yu, Zhang, Ni, Mok, Simon Wing Fai, Chen, Xi, Yu, Lu, Pan, Hudan, Hamdoun, Sami, Efferth, Thomas, Yu, Wen Jing, Zhang, Wei, Li, Zheng, Xie, Yuesheng, Luo, Riqiang, Jiang, Quan, Liu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637043/
https://www.ncbi.nlm.nih.gov/pubmed/31124139
http://dx.doi.org/10.1111/bph.14718

Ejemplares similares

Ejemplares similares