Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impact of these mutations on OPCML function, by solvin...

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Detalles Bibliográficos
Autores principales: Birtley, James R., Alomary, Mohammad, Zanini, Elisa, Antony, Jane, Maben, Zachary, Weaver, Grant C., Von Arx, Claudia, Mura, Manuela, Marinho, Aline T., Lu, Haonan, Morecroft, Eloise V. N., Karali, Evdoxia, Chayen, Naomi E., Tate, Edward W., Jurewicz, Mollie, Stern, Lawrence J., Recchi, Chiara, Gabra, Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637204/
https://www.ncbi.nlm.nih.gov/pubmed/31316070
http://dx.doi.org/10.1038/s41467-019-10966-8

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