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Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study

Introduction: Building upon the comorbidity between atopy and schizophrenia, we conducted a large cross-sectional, observational population-based study to examine if such associations also exist between atopic disorders (eczema, allergic rhinitis, and asthma) and nonclinical psychotic experiences. M...

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Autores principales: Begemann, Marieke J.H., Linszen, Mascha M.J., de Boer, Janna N., Hovenga, Wytske D., Gangadin, Shiral S., Schutte, Maya J.L., Sommer, Iris E.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637312/
https://www.ncbi.nlm.nih.gov/pubmed/31354535
http://dx.doi.org/10.3389/fpsyt.2019.00453
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author Begemann, Marieke J.H.
Linszen, Mascha M.J.
de Boer, Janna N.
Hovenga, Wytske D.
Gangadin, Shiral S.
Schutte, Maya J.L.
Sommer, Iris E.C.
author_facet Begemann, Marieke J.H.
Linszen, Mascha M.J.
de Boer, Janna N.
Hovenga, Wytske D.
Gangadin, Shiral S.
Schutte, Maya J.L.
Sommer, Iris E.C.
author_sort Begemann, Marieke J.H.
collection PubMed
description Introduction: Building upon the comorbidity between atopy and schizophrenia, we conducted a large cross-sectional, observational population-based study to examine if such associations also exist between atopic disorders (eczema, allergic rhinitis, and asthma) and nonclinical psychotic experiences. Methods: We examined psychotic experiences in a Dutch population sample through an online survey (≥14 years of age). Participants filled out the Questionnaire for Psychotic Experiences, together with questions screening for atopic disorders (eczema, allergic rhinitis, and asthma). Prevalence rates were calculated; binary logistic regression was used to determine odds ratios (ORs) (age, gender, and years of education as covariates). Results: We included 6,479 participants. Individuals diagnosed with one or more atopic disorders had an increased risk of psychotic experiences as compared with controls (OR = 1.26). Analysis of individual symptoms revealed an OR of 1.27 for hallucinations, whereas delusions only showed a trend. With each additional atopic disorder, the risk of psychotic experiences increased. This was also observed for hallucinations alone but not for delusions alone. Atopy was associated with hallucinations across all modalities (OR ranging from 1.19 to 1.40). These results did not appear to be driven specifically by any one of the atopic disorders. Conclusion: In the largest population sample of adolescents and adults to date, we found that atopic disorders (asthma, eczema, and allergic rhinitis) increase the risk of psychotic experiences, in a dose–response fashion. These results provide further support for the role of immunological components in the predisposition for psychosis and can serve as a base for further research.
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spelling pubmed-66373122019-07-26 Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study Begemann, Marieke J.H. Linszen, Mascha M.J. de Boer, Janna N. Hovenga, Wytske D. Gangadin, Shiral S. Schutte, Maya J.L. Sommer, Iris E.C. Front Psychiatry Psychiatry Introduction: Building upon the comorbidity between atopy and schizophrenia, we conducted a large cross-sectional, observational population-based study to examine if such associations also exist between atopic disorders (eczema, allergic rhinitis, and asthma) and nonclinical psychotic experiences. Methods: We examined psychotic experiences in a Dutch population sample through an online survey (≥14 years of age). Participants filled out the Questionnaire for Psychotic Experiences, together with questions screening for atopic disorders (eczema, allergic rhinitis, and asthma). Prevalence rates were calculated; binary logistic regression was used to determine odds ratios (ORs) (age, gender, and years of education as covariates). Results: We included 6,479 participants. Individuals diagnosed with one or more atopic disorders had an increased risk of psychotic experiences as compared with controls (OR = 1.26). Analysis of individual symptoms revealed an OR of 1.27 for hallucinations, whereas delusions only showed a trend. With each additional atopic disorder, the risk of psychotic experiences increased. This was also observed for hallucinations alone but not for delusions alone. Atopy was associated with hallucinations across all modalities (OR ranging from 1.19 to 1.40). These results did not appear to be driven specifically by any one of the atopic disorders. Conclusion: In the largest population sample of adolescents and adults to date, we found that atopic disorders (asthma, eczema, and allergic rhinitis) increase the risk of psychotic experiences, in a dose–response fashion. These results provide further support for the role of immunological components in the predisposition for psychosis and can serve as a base for further research. Frontiers Media S.A. 2019-07-09 /pmc/articles/PMC6637312/ /pubmed/31354535 http://dx.doi.org/10.3389/fpsyt.2019.00453 Text en Copyright © 2019 Begemann, Linszen, de Boer, Hovenga, Gangadin, Schutte and Sommer http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Begemann, Marieke J.H.
Linszen, Mascha M.J.
de Boer, Janna N.
Hovenga, Wytske D.
Gangadin, Shiral S.
Schutte, Maya J.L.
Sommer, Iris E.C.
Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study
title Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study
title_full Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study
title_fullStr Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study
title_full_unstemmed Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study
title_short Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study
title_sort atopy increases risk of psychotic experiences: a large population-based study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637312/
https://www.ncbi.nlm.nih.gov/pubmed/31354535
http://dx.doi.org/10.3389/fpsyt.2019.00453
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