Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

BACKGROUND: Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and treatment opportunities for high-risk individuals...

Descripción completa

Detalles Bibliográficos
Autores principales: Nones, K, Johnson, J, Newell, F, Patch, A M, Thorne, H, Kazakoff, S H, de Luca, X M, Parsons, M T, Ferguson, K, Reid, L E, McCart Reed, A E, Srihari, S, Lakis, V, Davidson, A L, Mukhopadhyay, P, Holmes, O, Xu, Q, Wood, S, Leonard, C, Beesley, J, Harris, J M, Barnes, D, Degasperi, A, Ragan, M A, Spurdle, A B, Khanna, K K, Lakhani, S R, Pearson, J V, Nik-Zainal, S, Chenevix-Trench, G, Waddell, N, Simpson, P T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637375/
https://www.ncbi.nlm.nih.gov/pubmed/31090900
http://dx.doi.org/10.1093/annonc/mdz132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637375/
https://www.ncbi.nlm.nih.gov/pubmed/31090900
http://dx.doi.org/10.1093/annonc/mdz132

Ejemplares similares