Cargando…

Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

OBJECTIVE: Primary Sjögren syndrome (pSS) is characterized by T and B cell infiltration of exocrine glands. The cysteine protease cathepsin S (CatS) is crucially involved in MHCII processing and T cell stimulation, and elevated levels have been found in patients with RA, psoriasis and pSS. However,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hargreaves, Patrick, Daoudlarian, Douglas, Theron, Michel, Kolb, Fabrice A., Manchester Young, Marianne, Reis, Bernhard, Tiaden, Andre, Bannert, Bettina, Kyburz, Diego, Manigold, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637481/ https://www.ncbi.nlm.nih.gov/pubmed/31319889 http://dx.doi.org/10.1186/s13075-019-1955-2

Ejemplares similares

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype
por: Quero, Lilian, et al.
Publicado: (2017)

Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance
por: Rahbar Saadat, Yalda, et al.
Publicado: (2022)

Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S
por: Theron, Michel, et al.
Publicado: (2017)

Assessing Genetic Variants in Matched Biocompartments From Patients With Serous Ovarian Cancer
por: Sanders, Brooke E., et al.
Publicado: (2021)

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus
por: Giaglis, Stavros, et al.
Publicado: (2021)

Mitochondrial DNA: a novel indicator of active inflammation in ANCA-associated vasculitides
por: Giaglis, Stavros, et al.
Publicado: (2023)

miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation
por: Quero, Lilian, et al.
Publicado: (2020)

Circulatory Neutrophils Exhibit Enhanced Neutrophil Extracellular Trap Formation in Early Puerperium: NETs at the Nexus of Thrombosis and Immunity
por: Giaglis, Stavros, et al.
Publicado: (2021)

Retinal Vessel Diameters and Physical Activity in Patients With Mild to Moderate Rheumatic Disease Without Cardiovascular Comorbidities
por: Deiseroth, Arne, et al.
Publicado: (2018)

α-Hydroxyketone Synthesis and Sensing by Legionella and Vibrio
por: Tiaden, André, et al.
Publicado: (2012)

Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren’s Syndrome
por: Klinngam, Wannita, et al.
Publicado: (2019)

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients
por: Edman, Maria C., et al.
Publicado: (2018)

Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren’s syndrome murine model
por: Fu, Runzhong, et al.
Publicado: (2020)

Sjögren’s syndrome
por: André, Fiona, et al.
Publicado: (2022)

Catatonia and Psychosis as Manifestations of Primary Sjögren’s Syndrome
por: Rosado, Steeve Neves, et al.
Publicado: (2018)

THE ESTIMATION OF CATHEPSIN WITH HEMOGLOBIN AND THE PARTIAL PURIFICATION OF CATHEPSIN
por: Anson, M. L.
Publicado: (1937)

Multiprofessioneller Behandlungsansatz bei chronischen Rückenschmerzen
por: Manigold, Tobias, et al.
Publicado: (2022)

Prostaglandin E(2) inhibits matrix mineralization by human bone marrow stromal cell-derived osteoblasts via Epac-dependent cAMP signaling
por: Mirsaidi, Ali, et al.
Publicado: (2017)

Why Provide an Opinions Section in PLoS Pathogens?
por: Manchester, Marianne
Publicado: (2005)

Cathepsin S as a target in gastric cancer
por: da Costa, Adriano Carneiro, et al.
Publicado: (2020)

THE PURIFICATION OF CATHEPSIN
por: Anson, M. L.
Publicado: (1940)

Synthesis, Characterization and in vitro Studies of a Cathepsin B‐Cleavable Prodrug of the VEGFR Inhibitor Sunitinib
por: Karnthaler‐Benbakka, Claudia, et al.
Publicado: (2018)

Differential Regulation of Cathepsin S and Cathepsin L in Interferon γ–treated Macrophages
por: Beers, Courtney, et al.
Publicado: (2003)

Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD
por: Nakajima, Takahiro, et al.
Publicado: (2016)

Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia
por: Song, Jingzhe, et al.
Publicado: (2023)

Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren’s Syndrome
por: Meng, Zhen, et al.
Publicado: (2017)

Cathepsins in digestive cancers
por: Chen, Siyuan, et al.
Publicado: (2017)

Cathepsins in neuronal plasticity
por: Tran, Amanda Phuong, et al.
Publicado: (2020)

Not all Sicca is Sjögren's and not all Sjögren's is Sicca
por: Neumann, Melissa, et al.
Publicado: (2021)

Primary Sjögren's syndrome: Longitudinal real‐world, observational data on health‐related quality of life
por: Tarn, Jessica, et al.
Publicado: (2022)

Karl Gustaf Torsten Sjögren and Sjögren-Larsson syndrome
por: Aboud, Khalid Al, et al.
Publicado: (2011)

Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis
por: Shriver, Leah P., et al.
Publicado: (2011)

Cathepsin L in unstable plaques
por: Bashir, Ayisha Z.
Publicado: (2020)

Host Cell Proteases: Cathepsins
por: Brix, Klaudia
Publicado: (2018)

Natural Products as Cathepsin Inhibitors
por: Vidal-Albalat, Andreu, et al.
Publicado: (2016)

Serum CXCL13 levels are associated with lymphoma risk and lymphoma occurrence in primary Sjögren’s syndrome
por: Traianos, Emmanuella Young, et al.
Publicado: (2020)

The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer
por: Pranjol, Md Zahidul Islam, et al.
Publicado: (2015)

Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors
por: Majc, Bernarda, et al.
Publicado: (2022)

All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma
por: van Mourik, Hester, et al.
Publicado: (2022)

Neuro-Sjögren: Peripheral Neuropathy With Limb Weakness in Sjögren's Syndrome
por: Seeliger, Tabea, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9betvau0sbkss5d57quua1ol0e