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Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma

BACKGROUND: Tralokinumab is an anti–interleukin (IL)-13 monoclonal antibody investigated for the treatment of severe, uncontrolled asthma in two Phase III clinical trials, STRATOS 1 and 2. The STRATOS 1 biomarker analysis plan was developed to identify biomarker(s) indicative of IL-13 activation lik...

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Detalles Bibliográficos
Autores principales:	Gottlow, Mattis, Svensson, David J., Lipkovich, Ilya, Huhn, Monika, Bowen, Karin, Wessman, Peter, Colice, Gene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Technical Advance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637533/ https://www.ncbi.nlm.nih.gov/pubmed/31315668 http://dx.doi.org/10.1186/s12890-019-0889-4

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