Cargando…

Regulation of Adaptive Immune Cells by Sirtuins

It is now well-established that the pathways that control lymphocyte metabolism and function are intimately linked, and changes in lymphocyte metabolism can influence and direct cellular function. Interestingly, a number of recent advances indicate that lymphocyte identity and metabolism is partiall...

Descripción completa

Detalles Bibliográficos
Autores principales: Warren, Jonathan L., MacIver, Nancie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637536/
https://www.ncbi.nlm.nih.gov/pubmed/31354630
http://dx.doi.org/10.3389/fendo.2019.00466
_version_ 1783436260273029120
author Warren, Jonathan L.
MacIver, Nancie J.
author_facet Warren, Jonathan L.
MacIver, Nancie J.
author_sort Warren, Jonathan L.
collection PubMed
description It is now well-established that the pathways that control lymphocyte metabolism and function are intimately linked, and changes in lymphocyte metabolism can influence and direct cellular function. Interestingly, a number of recent advances indicate that lymphocyte identity and metabolism is partially controlled via epigenetic regulation. Epigenetic mechanisms, such as changes in DNA methylation or histone acetylation, have been found to alter immune function and play a role in numerous chronic disease states. There are several enzymes that can mediate epigenetic changes; of particular interest are sirtuins, protein deacetylases that mediate adaptive responses to a variety of stresses (including calorie restriction and metabolic stress) and are now understood to play a significant role in immunity. This review will focus on recent advances in the understanding of how sirtuins affect the adaptive immune system. These pathways are of significant interest as therapeutic targets for the treatment of autoimmunity, cancer, and transplant tolerance.
format Online
Article
Text
id pubmed-6637536
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-66375362019-07-26 Regulation of Adaptive Immune Cells by Sirtuins Warren, Jonathan L. MacIver, Nancie J. Front Endocrinol (Lausanne) Endocrinology It is now well-established that the pathways that control lymphocyte metabolism and function are intimately linked, and changes in lymphocyte metabolism can influence and direct cellular function. Interestingly, a number of recent advances indicate that lymphocyte identity and metabolism is partially controlled via epigenetic regulation. Epigenetic mechanisms, such as changes in DNA methylation or histone acetylation, have been found to alter immune function and play a role in numerous chronic disease states. There are several enzymes that can mediate epigenetic changes; of particular interest are sirtuins, protein deacetylases that mediate adaptive responses to a variety of stresses (including calorie restriction and metabolic stress) and are now understood to play a significant role in immunity. This review will focus on recent advances in the understanding of how sirtuins affect the adaptive immune system. These pathways are of significant interest as therapeutic targets for the treatment of autoimmunity, cancer, and transplant tolerance. Frontiers Media S.A. 2019-07-11 /pmc/articles/PMC6637536/ /pubmed/31354630 http://dx.doi.org/10.3389/fendo.2019.00466 Text en Copyright © 2019 Warren and MacIver. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Warren, Jonathan L.
MacIver, Nancie J.
Regulation of Adaptive Immune Cells by Sirtuins
title Regulation of Adaptive Immune Cells by Sirtuins
title_full Regulation of Adaptive Immune Cells by Sirtuins
title_fullStr Regulation of Adaptive Immune Cells by Sirtuins
title_full_unstemmed Regulation of Adaptive Immune Cells by Sirtuins
title_short Regulation of Adaptive Immune Cells by Sirtuins
title_sort regulation of adaptive immune cells by sirtuins
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637536/
https://www.ncbi.nlm.nih.gov/pubmed/31354630
http://dx.doi.org/10.3389/fendo.2019.00466
work_keys_str_mv AT warrenjonathanl regulationofadaptiveimmunecellsbysirtuins
AT macivernanciej regulationofadaptiveimmunecellsbysirtuins