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Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study

BACKGROUND: Sclerostin, an antagonist of the Wingless-type mouse mammary tumor virus integration site (Wnt) pathway that regulates bone metabolism, is a potential contributor of chronic kidney disease (CKD)–mineral and bone disorder (MBD), which has various forms of presentation, from osteoporosis t...

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Autores principales: Kuo, Te-Hui, Lin, Wei-Hung, Chao, Jo-Yen, Wu, An-Bang, Tseng, Chin-Chung, Chang, Yu-Tzu, Liou, Hung-Hsiang, Wang, Ming-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637583/
https://www.ncbi.nlm.nih.gov/pubmed/31315601
http://dx.doi.org/10.1186/s12882-019-1452-5
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author Kuo, Te-Hui
Lin, Wei-Hung
Chao, Jo-Yen
Wu, An-Bang
Tseng, Chin-Chung
Chang, Yu-Tzu
Liou, Hung-Hsiang
Wang, Ming-Cheng
author_facet Kuo, Te-Hui
Lin, Wei-Hung
Chao, Jo-Yen
Wu, An-Bang
Tseng, Chin-Chung
Chang, Yu-Tzu
Liou, Hung-Hsiang
Wang, Ming-Cheng
author_sort Kuo, Te-Hui
collection PubMed
description BACKGROUND: Sclerostin, an antagonist of the Wingless-type mouse mammary tumor virus integration site (Wnt) pathway that regulates bone metabolism, is a potential contributor of chronic kidney disease (CKD)–mineral and bone disorder (MBD), which has various forms of presentation, from osteoporosis to vascular calcification. The positive association of sclerostin with bone mineral density (BMD) has been demonstrated in CKD and hemodialysis (HD) patients but not in peritoneal dialysis (PD) patients. This study assessed the association between sclerostin and BMD in PD patients. METHODS: Eighty-nine PD patients were enrolled; their sera were collected for measurement of sclerostin and other CKD–MBD-related markers. BMD was also assessed simultaneously. We examined the relationship between sclerostin and each parameter through Spearman correlation analysis and by comparing group data between patients with above- and below-median sclerostin levels. Univariate and multiple logistic regression models were employed to define the most predictive of sclerostin levels in the above-median category. RESULTS: Bivariate analysis revealed that sclerostin was correlated with spine BMD (r = 0.271, P = 0.011), spine BMD T-score (r = 0.274, P = 0.010), spine BMD Z-score (r = 0.237, P = 0.027), and intact parathyroid hormone (PTH; r = − 0.357, P < 0.001) after adjustments for age and sex. High BMD, old age, male sex, increased weight and height, diabetes, and high osteocalcin and uric acid levels were observed in patients with high serum sclerostin levels and an inverse relation was noticed between PTH and sclerostin. Univariate logistic regression analysis demonstrated that BMD is positively correlated with above-median sclerostin levels (odds ratio [OR] = 65.61, P = 0.002); the correlation was retained even after multivariate adjustment (OR = 121.5, P = 0.007). CONCLUSIONS: For the first time, this study demonstrated a positive association between serum sclerostin levels and BMD in the PD population.
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spelling pubmed-66375832019-07-25 Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study Kuo, Te-Hui Lin, Wei-Hung Chao, Jo-Yen Wu, An-Bang Tseng, Chin-Chung Chang, Yu-Tzu Liou, Hung-Hsiang Wang, Ming-Cheng BMC Nephrol Research Article BACKGROUND: Sclerostin, an antagonist of the Wingless-type mouse mammary tumor virus integration site (Wnt) pathway that regulates bone metabolism, is a potential contributor of chronic kidney disease (CKD)–mineral and bone disorder (MBD), which has various forms of presentation, from osteoporosis to vascular calcification. The positive association of sclerostin with bone mineral density (BMD) has been demonstrated in CKD and hemodialysis (HD) patients but not in peritoneal dialysis (PD) patients. This study assessed the association between sclerostin and BMD in PD patients. METHODS: Eighty-nine PD patients were enrolled; their sera were collected for measurement of sclerostin and other CKD–MBD-related markers. BMD was also assessed simultaneously. We examined the relationship between sclerostin and each parameter through Spearman correlation analysis and by comparing group data between patients with above- and below-median sclerostin levels. Univariate and multiple logistic regression models were employed to define the most predictive of sclerostin levels in the above-median category. RESULTS: Bivariate analysis revealed that sclerostin was correlated with spine BMD (r = 0.271, P = 0.011), spine BMD T-score (r = 0.274, P = 0.010), spine BMD Z-score (r = 0.237, P = 0.027), and intact parathyroid hormone (PTH; r = − 0.357, P < 0.001) after adjustments for age and sex. High BMD, old age, male sex, increased weight and height, diabetes, and high osteocalcin and uric acid levels were observed in patients with high serum sclerostin levels and an inverse relation was noticed between PTH and sclerostin. Univariate logistic regression analysis demonstrated that BMD is positively correlated with above-median sclerostin levels (odds ratio [OR] = 65.61, P = 0.002); the correlation was retained even after multivariate adjustment (OR = 121.5, P = 0.007). CONCLUSIONS: For the first time, this study demonstrated a positive association between serum sclerostin levels and BMD in the PD population. BioMed Central 2019-07-17 /pmc/articles/PMC6637583/ /pubmed/31315601 http://dx.doi.org/10.1186/s12882-019-1452-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kuo, Te-Hui
Lin, Wei-Hung
Chao, Jo-Yen
Wu, An-Bang
Tseng, Chin-Chung
Chang, Yu-Tzu
Liou, Hung-Hsiang
Wang, Ming-Cheng
Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
title Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
title_full Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
title_fullStr Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
title_full_unstemmed Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
title_short Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
title_sort serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637583/
https://www.ncbi.nlm.nih.gov/pubmed/31315601
http://dx.doi.org/10.1186/s12882-019-1452-5
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