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Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank

BACKGROUND: The associations between cardiovascular disease (CVD) risk factors and the biventricular geometry of the right ventricle (RV) and left ventricle (LV) have been difficult to assess, due to subtle and complex shape changes. We sought to quantify reference RV morphology as well as biventric...

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Autores principales: Mauger, Charlène, Gilbert, Kathleen, Lee, Aaron M., Sanghvi, Mihir M., Aung, Nay, Fung, Kenneth, Carapella, Valentina, Piechnik, Stefan K., Neubauer, Stefan, Petersen, Steffen E., Suinesiaputra, Avan, Young, Alistair A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637624/
https://www.ncbi.nlm.nih.gov/pubmed/31315625
http://dx.doi.org/10.1186/s12968-019-0551-6
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author Mauger, Charlène
Gilbert, Kathleen
Lee, Aaron M.
Sanghvi, Mihir M.
Aung, Nay
Fung, Kenneth
Carapella, Valentina
Piechnik, Stefan K.
Neubauer, Stefan
Petersen, Steffen E.
Suinesiaputra, Avan
Young, Alistair A.
author_facet Mauger, Charlène
Gilbert, Kathleen
Lee, Aaron M.
Sanghvi, Mihir M.
Aung, Nay
Fung, Kenneth
Carapella, Valentina
Piechnik, Stefan K.
Neubauer, Stefan
Petersen, Steffen E.
Suinesiaputra, Avan
Young, Alistair A.
author_sort Mauger, Charlène
collection PubMed
description BACKGROUND: The associations between cardiovascular disease (CVD) risk factors and the biventricular geometry of the right ventricle (RV) and left ventricle (LV) have been difficult to assess, due to subtle and complex shape changes. We sought to quantify reference RV morphology as well as biventricular variations associated with common cardiovascular risk factors. METHODS: A biventricular shape atlas was automatically constructed using contours and landmarks from 4329 UK Biobank cardiovascular magnetic resonance (CMR) studies. A subdivision surface geometric mesh was customized to the contours using a diffeomorphic registration algorithm, with automatic correction of slice shifts due to differences in breath-hold position. A reference sub-cohort was identified consisting of 630 participants with no CVD risk factors. Morphometric scores were computed using linear regression to quantify shape variations associated with four risk factors (high cholesterol, high blood pressure, obesity and smoking) and three disease factors (diabetes, previous myocardial infarction and angina). RESULTS: The atlas construction led to an accurate representation of 3D shapes at end-diastole and end-systole, with acceptable fitting errors between surfaces and contours (average error less than 1.5 mm). Atlas shape features had stronger associations than traditional mass and volume measures for all factors (p < 0.005 for each). High blood pressure was associated with outward displacement of the LV free walls, but inward displacement of the RV free wall and thickening of the septum. Smoking was associated with a rounder RV with inward displacement of the RV free wall and increased relative wall thickness. CONCLUSION: Morphometric relationships between biventricular shape and cardiovascular risk factors in a large cohort show complex interactions between RV and LV morphology. These can be quantified by z-scores, which can be used to study the morphological correlates of disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12968-019-0551-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-66376242019-07-25 Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank Mauger, Charlène Gilbert, Kathleen Lee, Aaron M. Sanghvi, Mihir M. Aung, Nay Fung, Kenneth Carapella, Valentina Piechnik, Stefan K. Neubauer, Stefan Petersen, Steffen E. Suinesiaputra, Avan Young, Alistair A. J Cardiovasc Magn Reson Research BACKGROUND: The associations between cardiovascular disease (CVD) risk factors and the biventricular geometry of the right ventricle (RV) and left ventricle (LV) have been difficult to assess, due to subtle and complex shape changes. We sought to quantify reference RV morphology as well as biventricular variations associated with common cardiovascular risk factors. METHODS: A biventricular shape atlas was automatically constructed using contours and landmarks from 4329 UK Biobank cardiovascular magnetic resonance (CMR) studies. A subdivision surface geometric mesh was customized to the contours using a diffeomorphic registration algorithm, with automatic correction of slice shifts due to differences in breath-hold position. A reference sub-cohort was identified consisting of 630 participants with no CVD risk factors. Morphometric scores were computed using linear regression to quantify shape variations associated with four risk factors (high cholesterol, high blood pressure, obesity and smoking) and three disease factors (diabetes, previous myocardial infarction and angina). RESULTS: The atlas construction led to an accurate representation of 3D shapes at end-diastole and end-systole, with acceptable fitting errors between surfaces and contours (average error less than 1.5 mm). Atlas shape features had stronger associations than traditional mass and volume measures for all factors (p < 0.005 for each). High blood pressure was associated with outward displacement of the LV free walls, but inward displacement of the RV free wall and thickening of the septum. Smoking was associated with a rounder RV with inward displacement of the RV free wall and increased relative wall thickness. CONCLUSION: Morphometric relationships between biventricular shape and cardiovascular risk factors in a large cohort show complex interactions between RV and LV morphology. These can be quantified by z-scores, which can be used to study the morphological correlates of disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12968-019-0551-6) contains supplementary material, which is available to authorized users. BioMed Central 2019-07-18 /pmc/articles/PMC6637624/ /pubmed/31315625 http://dx.doi.org/10.1186/s12968-019-0551-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mauger, Charlène
Gilbert, Kathleen
Lee, Aaron M.
Sanghvi, Mihir M.
Aung, Nay
Fung, Kenneth
Carapella, Valentina
Piechnik, Stefan K.
Neubauer, Stefan
Petersen, Steffen E.
Suinesiaputra, Avan
Young, Alistair A.
Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank
title Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank
title_full Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank
title_fullStr Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank
title_full_unstemmed Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank
title_short Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank
title_sort right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in uk biobank
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637624/
https://www.ncbi.nlm.nih.gov/pubmed/31315625
http://dx.doi.org/10.1186/s12968-019-0551-6
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