Cargando…

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand galectin-9 are involved in the immune escape of huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yasinska, Inna M., Sakhnevych, Svetlana S., Pavlova, Ludmila, Teo Hansen Selnø, Anette, Teuscher Abeleira, Ana Maria, Benlaouer, Ouafa, Gonçalves Silva, Isabel, Mosimann, Marianne, Varani, Luca, Bardelli, Marco, Hussain, Rohanah, Siligardi, Giuliano, Cholewa, Dietmar, Berger, Steffen M., Gibbs, Bernhard F., Ushkaryov, Yuri A., Fasler-Kan, Elizaveta, Klenova, Elena, Sumbayev, Vadim V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637653/ https://www.ncbi.nlm.nih.gov/pubmed/31354733 http://dx.doi.org/10.3389/fimmu.2019.01594

Ejemplares similares

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells
por: Gonçalves Silva, Isabel, et al.
Publicado: (2017)

Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
por: Sakhnevych, Svetlana S., et al.
Publicado: (2019)

High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells
por: Teo Hansen Selnø, Anette, et al.
Publicado: (2021)

Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells
por: Selnø, Anette Teo Hansen, et al.
Publicado: (2020)

The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells
por: Gonçalves Silva, Isabel, et al.
Publicado: (2016)

High mobility group box 1 (HMGB1) acts as an “alarmin” to promote acute myeloid leukaemia progression
por: Yasinska, Inna M., et al.
Publicado: (2018)

Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity
por: Yasinska, Inna M., et al.
Publicado: (2020)

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells
por: Silva, Isabel Gonçalves, et al.
Publicado: (2015)

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins
por: Schlichtner, Stephanie, et al.
Publicado: (2023)

Targeting of Basophil and Mast Cell Pro-Allergic Reactivity Using Functionalised Gold Nanoparticles
por: Yasinska, Inna M., et al.
Publicado: (2019)

L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes
por: Schlichtner, Stephanie, et al.
Publicado: (2023)

IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA)
por: Selnø, Anette T. Hansen, et al.
Publicado: (2023)

Alliance of galectin-3 and CD74 biochemical networks as a crucial component of survival machinery operated by human acute myeloid leukaemia cells
por: Yasinska, Inna M., et al.
Publicado: (2019)

129 Involvement of the Hypoxia-Inducible Factor-1 Transcription Complex in the Inflammatory Responses of Human Mast Cells and Basophils
por: Yasinska, Inna, et al.
Publicado: (2012)

61 Hypoxia-Inducible Factor 1 (HIF-1) Transcription is a “Signalling Driver” for Allergic Inflammation, Host Innate Immune Defence and Leukaemia Progression
por: Sumbayev, Vadim, et al.
Publicado: (2012)

Activation of immune evasion machinery is a part of the process of malignant transformation of human cells
por: Abooali, Maryam, et al.
Publicado: (2023)

Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells
por: Sumbayev, Vadim V., et al.
Publicado: (2016)

Editorial: Pathological reactions of cytotoxic lymphoid cells as universal therapeutic targets in cancer and autoimmune disease
por: Sumbayev, Vadim V., et al.
Publicado: (2023)

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity
por: Gibbs, Bernhard F., et al.
Publicado: (2015)

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells
por: Gibbs, Bernhard F., et al.
Publicado: (2011)

Tim3 binding to galectin-9 stimulates antimicrobial immunity
por: Jayaraman, Pushpa, et al.
Publicado: (2010)

TIM-3 Does Not Act as a Receptor for Galectin-9
por: Leitner, Judith, et al.
Publicado: (2013)

Nitric Oxide Activates Apoptosis Signal - Regulating Kinase 1 (ASK 1) Forming S-Nitrosothiols with Reactive Thioredoxin SH-Groups. Nitric Oxide Synthase (NOS) Induction Mediated Inhibition of Poly-(ADP-RIBOSE)-Polymerase (PARP) and Protein Kinase C (PKC) Activities as well as Intranucleosomal DNA Fragmentation (IDF) Increase in the HEP-2 Cells
por: Sumbayev, Vadim V., et al.
Publicado: (2001)

Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 – Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes
por: Schlichtner, Stephanie, et al.
Publicado: (2022)

Characterisation of Conformational and Ligand Binding Properties of Membrane Proteins Using Synchrotron Radiation Circular Dichroism (SRCD)
por: Hussain, Rohanah, et al.
Publicado: (2016)

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils
por: Sumbayev, Vadim V., et al.
Publicado: (2012)

UV-Denaturation Assay to Assess Protein Photostability and Ligand-Binding Interactions Using the High Photon Flux of Diamond B23 Beamline for SRCD
por: Hussain, Rohanah, et al.
Publicado: (2018)

Characterisation of sensor kinase by CD spectroscopy: golden rules and tips
por: Siligardi, Giuliano, et al.
Publicado: (2018)

CD Imaging at High Spatial Resolution at Diamond B23 Beamline: Evolution and Applications
por: Hussain, Rohanah, et al.
Publicado: (2021)

Interaction of Blenoxane and Congeners Bleomycins A2 and B2 with Human Plasma Proteins Using Circular Dichroism Spectroscopy
por: Longo, Edoardo, et al.
Publicado: (2023)

Free Radical Generation in Far-UV Synchrotron Radiation Circular Dichroism Assays—Protein and Buffer Composition Contribution
por: Ruzza, Paolo, et al.
Publicado: (2021)

Free Radicals and ROS Induce Protein Denaturation by UV Photostability Assay
por: Ruzza, Paolo, et al.
Publicado: (2021)

Involvement of Galectin-9/TIM-3 Pathway in the Systemic Inflammatory Response in Early-Onset Preeclampsia
por: Miko, Eva, et al.
Publicado: (2013)

Decreased Galectin-9 and Increased Tim-3 Expression Are Related to Poor Prognosis in Gastric Cancer
por: Jiang, Jing, et al.
Publicado: (2013)

High-throughput SRCD using multi-well plates and its applications
por: Hussain, Rohanah, et al.
Publicado: (2016)

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection
por: Nebbia, Gaia, et al.
Publicado: (2012)

Functional expression of Tim-3 on blasts and clinical impact of its ligand galectin-9 in myelodysplastic syndromes
por: Asayama, Toshio, et al.
Publicado: (2017)

Upregulated Tim-3/galectin-9 expressions in acute lung injury in a murine malarial model
por: Liu, Jinfeng, et al.
Publicado: (2015)

Peripheral Blood TIM-3 Positive NK and CD8+ T Cells throughout Pregnancy: TIM-3/Galectin-9 Interaction and Its Possible Role during Pregnancy
por: Meggyes, Matyas, et al.
Publicado: (2014)

Effect of Trehalose and Ceftriaxone on the Stability of Aggregating-Prone Tau Peptide Containing PHF6* Sequence: An SRCD Study
por: Honisch, Claudia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rg528l5qoeg1eorln8u98bm4tc