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Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus

We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diver...

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Detalles Bibliográficos
Autores principales: Guo, Ke, Li, Li-Li, Zhang, Qing, Yu, Jie-Mei, Ye, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637835/
https://www.ncbi.nlm.nih.gov/pubmed/31360058
http://dx.doi.org/10.1177/1176934319864922
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author Guo, Ke
Li, Li-Li
Zhang, Qing
Yu, Jie-Mei
Ye, Yan
author_facet Guo, Ke
Li, Li-Li
Zhang, Qing
Yu, Jie-Mei
Ye, Yan
author_sort Guo, Ke
collection PubMed
description We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years.
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spelling pubmed-66378352019-07-29 Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus Guo, Ke Li, Li-Li Zhang, Qing Yu, Jie-Mei Ye, Yan Evol Bioinform Online Rapid Communication We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years. SAGE Publications 2019-07-16 /pmc/articles/PMC6637835/ /pubmed/31360058 http://dx.doi.org/10.1177/1176934319864922 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Rapid Communication
Guo, Ke
Li, Li-Li
Zhang, Qing
Yu, Jie-Mei
Ye, Yan
Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus
title Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus
title_full Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus
title_fullStr Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus
title_full_unstemmed Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus
title_short Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus
title_sort diversified variants of astrovirus mlb2 in patients following hematopoietic stem cell transplantation and the evolutionary rates and patterns of the virus
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637835/
https://www.ncbi.nlm.nih.gov/pubmed/31360058
http://dx.doi.org/10.1177/1176934319864922
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