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Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly
The development of cortical convolutions, gyri and sulci, is a complex process that takes place during prenatal development. Lissencephaly, a rare genetic condition characterized by the lack of cortical convolutions, offers a model to look into biological processes that lead to the development of co...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637974/ https://www.ncbi.nlm.nih.gov/pubmed/31355197 http://dx.doi.org/10.3389/fcell.2019.00124 |
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author | Vasung, Lana Rezayev, Arthur Yun, Hyuk Jin Song, Jae W. van der Kouwe, Andre Stewart, Natalie Palani, Arthi Shiohama, Tadashi Chouinard-Decorte, Francois Levman, Jacob Takahashi, Emi |
author_facet | Vasung, Lana Rezayev, Arthur Yun, Hyuk Jin Song, Jae W. van der Kouwe, Andre Stewart, Natalie Palani, Arthi Shiohama, Tadashi Chouinard-Decorte, Francois Levman, Jacob Takahashi, Emi |
author_sort | Vasung, Lana |
collection | PubMed |
description | The development of cortical convolutions, gyri and sulci, is a complex process that takes place during prenatal development. Lissencephaly, a rare genetic condition characterized by the lack of cortical convolutions, offers a model to look into biological processes that lead to the development of convolutions. Retrospective, qualitative, and quantitative analyses of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed in patients with lissencephaly (N = 10) and age-/sex-matched controls (N = 10). In order to identify microstructural correlates of structural MRI and DTI findings, postmortem brains of patients with lissencephaly (N = 4) and age-matched controls (N = 4) were also examined with histology. Patients with lissencephaly had significantly smaller gyrification index and volumes of hemispheric white and gray matter, compared to the age-/sex-matched control group. However, there was no significant difference between groups in the subcortical gray matter volumes. Although the majority of patients with lissencephaly had a preserved normal-like appearance of major fissures and primary sulci, the spatial distribution of agyric cortical regions was different in patients with lissencephaly-1 (LIS1) and doublecortin (DCX) mutations. Lastly, in patients with lissencephaly, the spatiotemporal distribution of projection pathways was preserved while short- to medium-range cortico-cortical pathways were absent or fewer in number. Our results indicate that in the patients with lissencephaly cortical system is affected more than the subcortical one. |
format | Online Article Text |
id | pubmed-6637974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66379742019-07-26 Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly Vasung, Lana Rezayev, Arthur Yun, Hyuk Jin Song, Jae W. van der Kouwe, Andre Stewart, Natalie Palani, Arthi Shiohama, Tadashi Chouinard-Decorte, Francois Levman, Jacob Takahashi, Emi Front Cell Dev Biol Cell and Developmental Biology The development of cortical convolutions, gyri and sulci, is a complex process that takes place during prenatal development. Lissencephaly, a rare genetic condition characterized by the lack of cortical convolutions, offers a model to look into biological processes that lead to the development of convolutions. Retrospective, qualitative, and quantitative analyses of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed in patients with lissencephaly (N = 10) and age-/sex-matched controls (N = 10). In order to identify microstructural correlates of structural MRI and DTI findings, postmortem brains of patients with lissencephaly (N = 4) and age-matched controls (N = 4) were also examined with histology. Patients with lissencephaly had significantly smaller gyrification index and volumes of hemispheric white and gray matter, compared to the age-/sex-matched control group. However, there was no significant difference between groups in the subcortical gray matter volumes. Although the majority of patients with lissencephaly had a preserved normal-like appearance of major fissures and primary sulci, the spatial distribution of agyric cortical regions was different in patients with lissencephaly-1 (LIS1) and doublecortin (DCX) mutations. Lastly, in patients with lissencephaly, the spatiotemporal distribution of projection pathways was preserved while short- to medium-range cortico-cortical pathways were absent or fewer in number. Our results indicate that in the patients with lissencephaly cortical system is affected more than the subcortical one. Frontiers Media S.A. 2019-07-11 /pmc/articles/PMC6637974/ /pubmed/31355197 http://dx.doi.org/10.3389/fcell.2019.00124 Text en Copyright © 2019 Vasung, Rezayev, Yun, Song, van der Kouwe, Stewart, Palani, Shiohama, Chouinard-Decorte, Levman and Takahashi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Vasung, Lana Rezayev, Arthur Yun, Hyuk Jin Song, Jae W. van der Kouwe, Andre Stewart, Natalie Palani, Arthi Shiohama, Tadashi Chouinard-Decorte, Francois Levman, Jacob Takahashi, Emi Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly |
title | Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly |
title_full | Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly |
title_fullStr | Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly |
title_full_unstemmed | Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly |
title_short | Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly |
title_sort | structural and diffusion mri analyses with histological observations in patients with lissencephaly |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637974/ https://www.ncbi.nlm.nih.gov/pubmed/31355197 http://dx.doi.org/10.3389/fcell.2019.00124 |
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