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Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome

Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated with complex visual hallucinations in elderly people. Although studies suggested that visual hallucinations may be caused by brain damage in the visual system in CBS patients, alterations in specific brai...

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Autores principales: Martial, Charlotte, Larroque, Stephen Karl, Cavaliere, Carlo, Wannez, Sarah, Annen, Jitka, Kupers, Ron, Laureys, Steven, Di Perri, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638931/
https://www.ncbi.nlm.nih.gov/pubmed/31318888
http://dx.doi.org/10.1371/journal.pone.0219656
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author Martial, Charlotte
Larroque, Stephen Karl
Cavaliere, Carlo
Wannez, Sarah
Annen, Jitka
Kupers, Ron
Laureys, Steven
Di Perri, Carol
author_facet Martial, Charlotte
Larroque, Stephen Karl
Cavaliere, Carlo
Wannez, Sarah
Annen, Jitka
Kupers, Ron
Laureys, Steven
Di Perri, Carol
author_sort Martial, Charlotte
collection PubMed
description Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated with complex visual hallucinations in elderly people. Although studies suggested that visual hallucinations may be caused by brain damage in the visual system in CBS patients, alterations in specific brain regions in the occipital cortex have not been studied. Functional connectivity during resting-state functional magnetic resonance imaging (rs-fMRI; without hallucinations) in CBS patients, has never been explored. We aimed to investigate brain structural and functional changes in a patient with CBS, as compared with late blind (LB) and normally sighted subjects. We employed voxel-based morphometry and cortical thickness analyses to investigate alterations in grey matter characteristics, and rs-fMRI to study changes in functional brain connectivity. Decreased grey matter volume was observed in the middle occipital gyrus and in the cuneus in the CBS patient, and in the middle occipital gyrus and in the lingual gyrus within LB subjects, compared to their respective control groups. Reductions in cortical thickness in associative and multimodal cortices were observed in the CBS patient when comparing with LB subjects. The precuneus exhibited increased functional connectivity with the secondary visual cortex in the CBS patient compared to the controls. In contrast, LB patients showed decreased functional connectivity compared to sighted controls between the DMN and the temporo-occipital fusiform gyrus, a region known to support hallucinations. Our findings suggest a reorganization of the functional connectivity between regions involved in self-awareness and in visual and salience processing in CBS that may contribute to the appearance of visual hallucinations.
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spelling pubmed-66389312019-07-25 Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome Martial, Charlotte Larroque, Stephen Karl Cavaliere, Carlo Wannez, Sarah Annen, Jitka Kupers, Ron Laureys, Steven Di Perri, Carol PLoS One Research Article Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated with complex visual hallucinations in elderly people. Although studies suggested that visual hallucinations may be caused by brain damage in the visual system in CBS patients, alterations in specific brain regions in the occipital cortex have not been studied. Functional connectivity during resting-state functional magnetic resonance imaging (rs-fMRI; without hallucinations) in CBS patients, has never been explored. We aimed to investigate brain structural and functional changes in a patient with CBS, as compared with late blind (LB) and normally sighted subjects. We employed voxel-based morphometry and cortical thickness analyses to investigate alterations in grey matter characteristics, and rs-fMRI to study changes in functional brain connectivity. Decreased grey matter volume was observed in the middle occipital gyrus and in the cuneus in the CBS patient, and in the middle occipital gyrus and in the lingual gyrus within LB subjects, compared to their respective control groups. Reductions in cortical thickness in associative and multimodal cortices were observed in the CBS patient when comparing with LB subjects. The precuneus exhibited increased functional connectivity with the secondary visual cortex in the CBS patient compared to the controls. In contrast, LB patients showed decreased functional connectivity compared to sighted controls between the DMN and the temporo-occipital fusiform gyrus, a region known to support hallucinations. Our findings suggest a reorganization of the functional connectivity between regions involved in self-awareness and in visual and salience processing in CBS that may contribute to the appearance of visual hallucinations. Public Library of Science 2019-07-18 /pmc/articles/PMC6638931/ /pubmed/31318888 http://dx.doi.org/10.1371/journal.pone.0219656 Text en © 2019 Martial et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Martial, Charlotte
Larroque, Stephen Karl
Cavaliere, Carlo
Wannez, Sarah
Annen, Jitka
Kupers, Ron
Laureys, Steven
Di Perri, Carol
Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
title Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
title_full Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
title_fullStr Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
title_full_unstemmed Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
title_short Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
title_sort resting-state functional connectivity and cortical thickness characterization of a patient with charles bonnet syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638931/
https://www.ncbi.nlm.nih.gov/pubmed/31318888
http://dx.doi.org/10.1371/journal.pone.0219656
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