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Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome
Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated with complex visual hallucinations in elderly people. Although studies suggested that visual hallucinations may be caused by brain damage in the visual system in CBS patients, alterations in specific brai...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638931/ https://www.ncbi.nlm.nih.gov/pubmed/31318888 http://dx.doi.org/10.1371/journal.pone.0219656 |
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author | Martial, Charlotte Larroque, Stephen Karl Cavaliere, Carlo Wannez, Sarah Annen, Jitka Kupers, Ron Laureys, Steven Di Perri, Carol |
author_facet | Martial, Charlotte Larroque, Stephen Karl Cavaliere, Carlo Wannez, Sarah Annen, Jitka Kupers, Ron Laureys, Steven Di Perri, Carol |
author_sort | Martial, Charlotte |
collection | PubMed |
description | Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated with complex visual hallucinations in elderly people. Although studies suggested that visual hallucinations may be caused by brain damage in the visual system in CBS patients, alterations in specific brain regions in the occipital cortex have not been studied. Functional connectivity during resting-state functional magnetic resonance imaging (rs-fMRI; without hallucinations) in CBS patients, has never been explored. We aimed to investigate brain structural and functional changes in a patient with CBS, as compared with late blind (LB) and normally sighted subjects. We employed voxel-based morphometry and cortical thickness analyses to investigate alterations in grey matter characteristics, and rs-fMRI to study changes in functional brain connectivity. Decreased grey matter volume was observed in the middle occipital gyrus and in the cuneus in the CBS patient, and in the middle occipital gyrus and in the lingual gyrus within LB subjects, compared to their respective control groups. Reductions in cortical thickness in associative and multimodal cortices were observed in the CBS patient when comparing with LB subjects. The precuneus exhibited increased functional connectivity with the secondary visual cortex in the CBS patient compared to the controls. In contrast, LB patients showed decreased functional connectivity compared to sighted controls between the DMN and the temporo-occipital fusiform gyrus, a region known to support hallucinations. Our findings suggest a reorganization of the functional connectivity between regions involved in self-awareness and in visual and salience processing in CBS that may contribute to the appearance of visual hallucinations. |
format | Online Article Text |
id | pubmed-6638931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-66389312019-07-25 Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome Martial, Charlotte Larroque, Stephen Karl Cavaliere, Carlo Wannez, Sarah Annen, Jitka Kupers, Ron Laureys, Steven Di Perri, Carol PLoS One Research Article Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated with complex visual hallucinations in elderly people. Although studies suggested that visual hallucinations may be caused by brain damage in the visual system in CBS patients, alterations in specific brain regions in the occipital cortex have not been studied. Functional connectivity during resting-state functional magnetic resonance imaging (rs-fMRI; without hallucinations) in CBS patients, has never been explored. We aimed to investigate brain structural and functional changes in a patient with CBS, as compared with late blind (LB) and normally sighted subjects. We employed voxel-based morphometry and cortical thickness analyses to investigate alterations in grey matter characteristics, and rs-fMRI to study changes in functional brain connectivity. Decreased grey matter volume was observed in the middle occipital gyrus and in the cuneus in the CBS patient, and in the middle occipital gyrus and in the lingual gyrus within LB subjects, compared to their respective control groups. Reductions in cortical thickness in associative and multimodal cortices were observed in the CBS patient when comparing with LB subjects. The precuneus exhibited increased functional connectivity with the secondary visual cortex in the CBS patient compared to the controls. In contrast, LB patients showed decreased functional connectivity compared to sighted controls between the DMN and the temporo-occipital fusiform gyrus, a region known to support hallucinations. Our findings suggest a reorganization of the functional connectivity between regions involved in self-awareness and in visual and salience processing in CBS that may contribute to the appearance of visual hallucinations. Public Library of Science 2019-07-18 /pmc/articles/PMC6638931/ /pubmed/31318888 http://dx.doi.org/10.1371/journal.pone.0219656 Text en © 2019 Martial et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Martial, Charlotte Larroque, Stephen Karl Cavaliere, Carlo Wannez, Sarah Annen, Jitka Kupers, Ron Laureys, Steven Di Perri, Carol Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome |
title | Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome |
title_full | Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome |
title_fullStr | Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome |
title_full_unstemmed | Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome |
title_short | Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome |
title_sort | resting-state functional connectivity and cortical thickness characterization of a patient with charles bonnet syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638931/ https://www.ncbi.nlm.nih.gov/pubmed/31318888 http://dx.doi.org/10.1371/journal.pone.0219656 |
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