Cargando…

Risk factor analysis for the development and progression of retinopathy of prematurity

PURPOSE: To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP). METHODS: The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewe...

Descripción completa

Detalles Bibliográficos
Autor principal: Chang, Ji Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638955/
https://www.ncbi.nlm.nih.gov/pubmed/31318921
http://dx.doi.org/10.1371/journal.pone.0219934
_version_ 1783436383089590272
author Chang, Ji Woong
author_facet Chang, Ji Woong
author_sort Chang, Ji Woong
collection PubMed
description PURPOSE: To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP). METHODS: The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewed. Twenty potential risk factors that may influence the development or progression of ROP were analyzed by univariate and multivariate logistic regression analyses. The progression of ROP was defined as type 1 ROP, threshold ROP, or aggressive posterior ROP for which treatment was recommended. RESULTS: A total of 324 eyes were included; 157 eyes (48.5%) showed ROP development, and 48 eyes exhibited ROP progression (14.8% of all eyes and 30.6% of the ROP-developed eyes). According to the univariate and multivariate logistic regression analyses, prenatal steroid use, GA, the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP. However, GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression. CONCLUSION: The risk factors that influenced ROP development versus ROP progression were not identical. Evaluating these risk factors during screening of high-risk premature infants will help determine the appropriate timing of examinations and treatment.
format Online
Article
Text
id pubmed-6638955
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-66389552019-07-25 Risk factor analysis for the development and progression of retinopathy of prematurity Chang, Ji Woong PLoS One Research Article PURPOSE: To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP). METHODS: The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewed. Twenty potential risk factors that may influence the development or progression of ROP were analyzed by univariate and multivariate logistic regression analyses. The progression of ROP was defined as type 1 ROP, threshold ROP, or aggressive posterior ROP for which treatment was recommended. RESULTS: A total of 324 eyes were included; 157 eyes (48.5%) showed ROP development, and 48 eyes exhibited ROP progression (14.8% of all eyes and 30.6% of the ROP-developed eyes). According to the univariate and multivariate logistic regression analyses, prenatal steroid use, GA, the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP. However, GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression. CONCLUSION: The risk factors that influenced ROP development versus ROP progression were not identical. Evaluating these risk factors during screening of high-risk premature infants will help determine the appropriate timing of examinations and treatment. Public Library of Science 2019-07-18 /pmc/articles/PMC6638955/ /pubmed/31318921 http://dx.doi.org/10.1371/journal.pone.0219934 Text en © 2019 Ji Woong Chang http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chang, Ji Woong
Risk factor analysis for the development and progression of retinopathy of prematurity
title Risk factor analysis for the development and progression of retinopathy of prematurity
title_full Risk factor analysis for the development and progression of retinopathy of prematurity
title_fullStr Risk factor analysis for the development and progression of retinopathy of prematurity
title_full_unstemmed Risk factor analysis for the development and progression of retinopathy of prematurity
title_short Risk factor analysis for the development and progression of retinopathy of prematurity
title_sort risk factor analysis for the development and progression of retinopathy of prematurity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638955/
https://www.ncbi.nlm.nih.gov/pubmed/31318921
http://dx.doi.org/10.1371/journal.pone.0219934
work_keys_str_mv AT changjiwoong riskfactoranalysisforthedevelopmentandprogressionofretinopathyofprematurity