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Risk factor analysis for the development and progression of retinopathy of prematurity
PURPOSE: To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP). METHODS: The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewe...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638955/ https://www.ncbi.nlm.nih.gov/pubmed/31318921 http://dx.doi.org/10.1371/journal.pone.0219934 |
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author | Chang, Ji Woong |
author_facet | Chang, Ji Woong |
author_sort | Chang, Ji Woong |
collection | PubMed |
description | PURPOSE: To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP). METHODS: The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewed. Twenty potential risk factors that may influence the development or progression of ROP were analyzed by univariate and multivariate logistic regression analyses. The progression of ROP was defined as type 1 ROP, threshold ROP, or aggressive posterior ROP for which treatment was recommended. RESULTS: A total of 324 eyes were included; 157 eyes (48.5%) showed ROP development, and 48 eyes exhibited ROP progression (14.8% of all eyes and 30.6% of the ROP-developed eyes). According to the univariate and multivariate logistic regression analyses, prenatal steroid use, GA, the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP. However, GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression. CONCLUSION: The risk factors that influenced ROP development versus ROP progression were not identical. Evaluating these risk factors during screening of high-risk premature infants will help determine the appropriate timing of examinations and treatment. |
format | Online Article Text |
id | pubmed-6638955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-66389552019-07-25 Risk factor analysis for the development and progression of retinopathy of prematurity Chang, Ji Woong PLoS One Research Article PURPOSE: To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP). METHODS: The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewed. Twenty potential risk factors that may influence the development or progression of ROP were analyzed by univariate and multivariate logistic regression analyses. The progression of ROP was defined as type 1 ROP, threshold ROP, or aggressive posterior ROP for which treatment was recommended. RESULTS: A total of 324 eyes were included; 157 eyes (48.5%) showed ROP development, and 48 eyes exhibited ROP progression (14.8% of all eyes and 30.6% of the ROP-developed eyes). According to the univariate and multivariate logistic regression analyses, prenatal steroid use, GA, the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP. However, GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression. CONCLUSION: The risk factors that influenced ROP development versus ROP progression were not identical. Evaluating these risk factors during screening of high-risk premature infants will help determine the appropriate timing of examinations and treatment. Public Library of Science 2019-07-18 /pmc/articles/PMC6638955/ /pubmed/31318921 http://dx.doi.org/10.1371/journal.pone.0219934 Text en © 2019 Ji Woong Chang http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Chang, Ji Woong Risk factor analysis for the development and progression of retinopathy of prematurity |
title | Risk factor analysis for the development and progression of retinopathy of prematurity |
title_full | Risk factor analysis for the development and progression of retinopathy of prematurity |
title_fullStr | Risk factor analysis for the development and progression of retinopathy of prematurity |
title_full_unstemmed | Risk factor analysis for the development and progression of retinopathy of prematurity |
title_short | Risk factor analysis for the development and progression of retinopathy of prematurity |
title_sort | risk factor analysis for the development and progression of retinopathy of prematurity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638955/ https://www.ncbi.nlm.nih.gov/pubmed/31318921 http://dx.doi.org/10.1371/journal.pone.0219934 |
work_keys_str_mv | AT changjiwoong riskfactoranalysisforthedevelopmentandprogressionofretinopathyofprematurity |