Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

The chemical diversification of natural products provides a robust and general method for creation of stereochemically rich and structurally diverse small molecules. The resulting compounds have physicochemical traits different from those in most screening collections, and as such are an excellent s...

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Detalles Bibliográficos
Autores principales: Llabani, Evijola, Hicklin, Robert W., Lee, Hyang Yeon, Motika, Stephen E., Crawford, Lisa A., Weerapana, Eranthie, Hergenrother, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639018/
https://www.ncbi.nlm.nih.gov/pubmed/31086302
http://dx.doi.org/10.1038/s41557-019-0261-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639018/
https://www.ncbi.nlm.nih.gov/pubmed/31086302
http://dx.doi.org/10.1038/s41557-019-0261-6

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