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Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis
The chemical diversification of natural products provides a robust and general method for creation of stereochemically rich and structurally diverse small molecules. The resulting compounds have physicochemical traits different from those in most screening collections, and as such are an excellent s...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639018/ https://www.ncbi.nlm.nih.gov/pubmed/31086302 http://dx.doi.org/10.1038/s41557-019-0261-6 |