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PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis
OBJECTIVE: The significance of gene methylation in peripheral blood leukocytes (PBLs) for assessing cancer prognosis is poorly understood. Our purpose is to assess the association between PBX3 methylation in PBLs and colorectal cancer (CRC) prognosis. METHODS: A total of 369 CRC patients were follow...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639175/ https://www.ncbi.nlm.nih.gov/pubmed/31140752 http://dx.doi.org/10.1002/cam4.2321 |
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author | Sun, Hongru Huang, Hao Li, Dapeng Zhang, Lei Zhang, Yuanyuan Xu, Jing Liu, Ying Liu, Yupeng Zhao, Yashuang |
author_facet | Sun, Hongru Huang, Hao Li, Dapeng Zhang, Lei Zhang, Yuanyuan Xu, Jing Liu, Ying Liu, Yupeng Zhao, Yashuang |
author_sort | Sun, Hongru |
collection | PubMed |
description | OBJECTIVE: The significance of gene methylation in peripheral blood leukocytes (PBLs) for assessing cancer prognosis is poorly understood. Our purpose is to assess the association between PBX3 methylation in PBLs and colorectal cancer (CRC) prognosis. METHODS: A total of 369 CRC patients were followed up for up to 10 years in this cohort study. PBL PBX3 methylation levels were determined by methylation‐sensitive high‐resolution melting. Cox regression models and Log‐rank tests were used to analyze the associations between PBX3 methylation status and CRC prognosis with a propensity score (PS) method to control confounding biases. RESULTS: In this study, we found that CRC patients with PBL PBX3 hypermethylation status had a better overall survival (OS) (hazard ratio [HR(PS‐adjusted)], 0.72 [95% CI, 0.52‐1.00]; P = 0.049). Subgroup analyses showed that the beneficial effect of PBX3 hypermethylation status on CRC 10‐years OS remained significant among UICC stage III patients ([HR(PS‐adjusted)], 0.60 [95% CI, 0.38 to 0.95]; P = 0.029) and colon cancer patients ([HR(PS‐adjusted)], 0.49 [95% CI, 0.26 to 0.92]; P = 0.027). CONCLUSION: PBL PBX3 hypermethylation is positively associated with better prognosis of CRC, especially for the UICC stage III CRC patients and colon cancer patients. |
format | Online Article Text |
id | pubmed-6639175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66391752019-07-29 PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis Sun, Hongru Huang, Hao Li, Dapeng Zhang, Lei Zhang, Yuanyuan Xu, Jing Liu, Ying Liu, Yupeng Zhao, Yashuang Cancer Med Cancer Prevention OBJECTIVE: The significance of gene methylation in peripheral blood leukocytes (PBLs) for assessing cancer prognosis is poorly understood. Our purpose is to assess the association between PBX3 methylation in PBLs and colorectal cancer (CRC) prognosis. METHODS: A total of 369 CRC patients were followed up for up to 10 years in this cohort study. PBL PBX3 methylation levels were determined by methylation‐sensitive high‐resolution melting. Cox regression models and Log‐rank tests were used to analyze the associations between PBX3 methylation status and CRC prognosis with a propensity score (PS) method to control confounding biases. RESULTS: In this study, we found that CRC patients with PBL PBX3 hypermethylation status had a better overall survival (OS) (hazard ratio [HR(PS‐adjusted)], 0.72 [95% CI, 0.52‐1.00]; P = 0.049). Subgroup analyses showed that the beneficial effect of PBX3 hypermethylation status on CRC 10‐years OS remained significant among UICC stage III patients ([HR(PS‐adjusted)], 0.60 [95% CI, 0.38 to 0.95]; P = 0.029) and colon cancer patients ([HR(PS‐adjusted)], 0.49 [95% CI, 0.26 to 0.92]; P = 0.027). CONCLUSION: PBL PBX3 hypermethylation is positively associated with better prognosis of CRC, especially for the UICC stage III CRC patients and colon cancer patients. John Wiley and Sons Inc. 2019-05-29 /pmc/articles/PMC6639175/ /pubmed/31140752 http://dx.doi.org/10.1002/cam4.2321 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Sun, Hongru Huang, Hao Li, Dapeng Zhang, Lei Zhang, Yuanyuan Xu, Jing Liu, Ying Liu, Yupeng Zhao, Yashuang PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis |
title |
PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis |
title_full |
PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis |
title_fullStr |
PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis |
title_full_unstemmed |
PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis |
title_short |
PBX3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: A propensity score analysis |
title_sort | pbx3 hypermethylation in peripheral blood leukocytes predicts better prognosis in colorectal cancer: a propensity score analysis |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639175/ https://www.ncbi.nlm.nih.gov/pubmed/31140752 http://dx.doi.org/10.1002/cam4.2321 |
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