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Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene expression principally via shortening of poly(A) tails of messenger RNA or deadenylation. Here, we reconstitute a complete, recombinant human CCR4-NOT complex. Our reconstitution strategy permits strict compositional contro...
Autores principales: | Raisch, Tobias, Chang, Chung-Te, Levdansky, Yevgen, Muthukumar, Sowndarya, Raunser, Stefan, Valkov, Eugene |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639331/ https://www.ncbi.nlm.nih.gov/pubmed/31320642 http://dx.doi.org/10.1038/s41467-019-11094-z |
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