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Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China
Screening is an effective measure to prevent and control colorectal cancer (CRC). A mass CRC screening programme was conducted in Guangzhou from 2015 to 2017. Public media and reminders from a mobile short message service were used to invite residents aged between 50 and 74 years. A high-risk factor...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639356/ https://www.ncbi.nlm.nih.gov/pubmed/31320661 http://dx.doi.org/10.1038/s41598-019-46670-2 |
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author | Lin, Guozhen Feng, Zhiqiang Liu, Huazhang Li, Yan Nie, Yuqiang Liang, Yingru Li, Ke |
author_facet | Lin, Guozhen Feng, Zhiqiang Liu, Huazhang Li, Yan Nie, Yuqiang Liang, Yingru Li, Ke |
author_sort | Lin, Guozhen |
collection | PubMed |
description | Screening is an effective measure to prevent and control colorectal cancer (CRC). A mass CRC screening programme was conducted in Guangzhou from 2015 to 2017. Public media and reminders from a mobile short message service were used to invite residents aged between 50 and 74 years. A high-risk factor questionnaire (HRFQ) and biennial faecal immunochemical testing (FIT) were chosen as the primary screening methods, and individuals with a positive test result were referred to a defined hospital for an assessment colonoscopy. During the 3 years, 350,581 residents of the total eligible population of 2,283,214 attended the free first stage of screening. In all, 91.0% of the participants finished the HRFQs and FITs. The total uptake rate was 15.4%, which increased with age, female sex, and rural location. There was 15.9% positivity in the first stage of screening, including 8.5% positive HRFQs, 6.2% positive FITs and 1.2% positive HRFQs and FITs. In total, 10,600 individuals with positive HRFQs/FITs completed an assessment colonoscopy. The total uptake rate of colonoscopies was 18.9%, which decreased with age and female sex. Three hundred fifty-one CRCs and 980 advanced adenomas (AAs) were diagnosed with positive predictive values (PPV) of 3.3% and 9.2%, respectively. The PPVs of CRCs in the exclusively FIT-positive population were 4.9%, which was 10 times greater than in the exclusively HRFQ-positive population (0.5%). The PPVs of CRCs and AAs increased with age and male sex. The detection ratio of localized CRCs (including stage I and stage II) increased 68.1% due to screening. Although the compliance rate was low, the PPVs for CRCs and AAs were high. More effective mobilization of the programme’s needs and subsidies for colonoscopies should be taken into account to increase compliance. |
format | Online Article Text |
id | pubmed-6639356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66393562019-07-25 Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China Lin, Guozhen Feng, Zhiqiang Liu, Huazhang Li, Yan Nie, Yuqiang Liang, Yingru Li, Ke Sci Rep Article Screening is an effective measure to prevent and control colorectal cancer (CRC). A mass CRC screening programme was conducted in Guangzhou from 2015 to 2017. Public media and reminders from a mobile short message service were used to invite residents aged between 50 and 74 years. A high-risk factor questionnaire (HRFQ) and biennial faecal immunochemical testing (FIT) were chosen as the primary screening methods, and individuals with a positive test result were referred to a defined hospital for an assessment colonoscopy. During the 3 years, 350,581 residents of the total eligible population of 2,283,214 attended the free first stage of screening. In all, 91.0% of the participants finished the HRFQs and FITs. The total uptake rate was 15.4%, which increased with age, female sex, and rural location. There was 15.9% positivity in the first stage of screening, including 8.5% positive HRFQs, 6.2% positive FITs and 1.2% positive HRFQs and FITs. In total, 10,600 individuals with positive HRFQs/FITs completed an assessment colonoscopy. The total uptake rate of colonoscopies was 18.9%, which decreased with age and female sex. Three hundred fifty-one CRCs and 980 advanced adenomas (AAs) were diagnosed with positive predictive values (PPV) of 3.3% and 9.2%, respectively. The PPVs of CRCs in the exclusively FIT-positive population were 4.9%, which was 10 times greater than in the exclusively HRFQ-positive population (0.5%). The PPVs of CRCs and AAs increased with age and male sex. The detection ratio of localized CRCs (including stage I and stage II) increased 68.1% due to screening. Although the compliance rate was low, the PPVs for CRCs and AAs were high. More effective mobilization of the programme’s needs and subsidies for colonoscopies should be taken into account to increase compliance. Nature Publishing Group UK 2019-07-18 /pmc/articles/PMC6639356/ /pubmed/31320661 http://dx.doi.org/10.1038/s41598-019-46670-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lin, Guozhen Feng, Zhiqiang Liu, Huazhang Li, Yan Nie, Yuqiang Liang, Yingru Li, Ke Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China |
title | Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China |
title_full | Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China |
title_fullStr | Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China |
title_full_unstemmed | Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China |
title_short | Mass screening for colorectal cancer in a population of two million older adults in Guangzhou, China |
title_sort | mass screening for colorectal cancer in a population of two million older adults in guangzhou, china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639356/ https://www.ncbi.nlm.nih.gov/pubmed/31320661 http://dx.doi.org/10.1038/s41598-019-46670-2 |
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