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Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify because of the mechanistic coupling of noise to mean expression. To independently quantify the effects of changes in mean expression and noise we determine the fitness landscapes in mean-noise expressi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639414/ https://www.ncbi.nlm.nih.gov/pubmed/31320634 http://dx.doi.org/10.1038/s41467-019-11116-w |