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Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis
BACKGROUND: Steroid‐responsive meningitis‐arteritis (SRMA) is a common inflammatory neurologic disorder of dogs for which certain breeds are predisposed. OBJECTIVES: To determine whether breed differences exist in clinical features, treatment response, and relapse in a population of North American d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639478/ https://www.ncbi.nlm.nih.gov/pubmed/31175683 http://dx.doi.org/10.1111/jvim.15543 |
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author | Lau, Jeanie Nettifee, Julie A. Early, Peter J. Mariani, Christopher L. Olby, Natasha J. Muñana, Karen R. |
author_facet | Lau, Jeanie Nettifee, Julie A. Early, Peter J. Mariani, Christopher L. Olby, Natasha J. Muñana, Karen R. |
author_sort | Lau, Jeanie |
collection | PubMed |
description | BACKGROUND: Steroid‐responsive meningitis‐arteritis (SRMA) is a common inflammatory neurologic disorder of dogs for which certain breeds are predisposed. OBJECTIVES: To determine whether breed differences exist in clinical features, treatment response, and relapse in a population of North American dogs with SRMA, and to evaluate the effect of disease on dogs' quality of life (QoL). ANIMALS: Sixty‐one client‐owned dogs with SRMA: 29 dogs identified through an American Kennel Club‐Canine Health Foundation survey and 32 dogs from North Carolina (NC) State Veterinary Hospital. METHODS: Retrospective case series. Caregivers completed an online survey to assess QoL. RESULTS: Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty‐nine dogs (48%) had ≥1 disease relapse. There was a significant effect of cerebrospinal fluid nucleated cell count on the frequency of disease relapse (P = .003), but no relationship was identified between treatment protocol and relapse. Dogs' QoL was associated with the severity of corticosteroid‐related adverse effects (P = .03), which were dose‐related (r = .24, P = .02) and more prevalent in Wirehaired Pointing Griffons than in other breeds (P = .04). CONCLUSION AND CLINICAL IMPORTANCE: Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA. Treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL, but it may not improve clinical outcome. |
format | Online Article Text |
id | pubmed-6639478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66394782019-07-29 Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis Lau, Jeanie Nettifee, Julie A. Early, Peter J. Mariani, Christopher L. Olby, Natasha J. Muñana, Karen R. J Vet Intern Med SMALL ANIMAL BACKGROUND: Steroid‐responsive meningitis‐arteritis (SRMA) is a common inflammatory neurologic disorder of dogs for which certain breeds are predisposed. OBJECTIVES: To determine whether breed differences exist in clinical features, treatment response, and relapse in a population of North American dogs with SRMA, and to evaluate the effect of disease on dogs' quality of life (QoL). ANIMALS: Sixty‐one client‐owned dogs with SRMA: 29 dogs identified through an American Kennel Club‐Canine Health Foundation survey and 32 dogs from North Carolina (NC) State Veterinary Hospital. METHODS: Retrospective case series. Caregivers completed an online survey to assess QoL. RESULTS: Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty‐nine dogs (48%) had ≥1 disease relapse. There was a significant effect of cerebrospinal fluid nucleated cell count on the frequency of disease relapse (P = .003), but no relationship was identified between treatment protocol and relapse. Dogs' QoL was associated with the severity of corticosteroid‐related adverse effects (P = .03), which were dose‐related (r = .24, P = .02) and more prevalent in Wirehaired Pointing Griffons than in other breeds (P = .04). CONCLUSION AND CLINICAL IMPORTANCE: Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA. Treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL, but it may not improve clinical outcome. John Wiley & Sons, Inc. 2019-06-07 2019 /pmc/articles/PMC6639478/ /pubmed/31175683 http://dx.doi.org/10.1111/jvim.15543 Text en © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Lau, Jeanie Nettifee, Julie A. Early, Peter J. Mariani, Christopher L. Olby, Natasha J. Muñana, Karen R. Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
title | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
title_full | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
title_fullStr | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
title_full_unstemmed | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
title_short | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
title_sort | clinical characteristics, breed differences, and quality of life in north american dogs with acute steroid‐responsive meningitis‐arteritis |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639478/ https://www.ncbi.nlm.nih.gov/pubmed/31175683 http://dx.doi.org/10.1111/jvim.15543 |
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