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Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures
BACKGROUND: Treatment options for at‐home management of cluster seizures (CS) and status epilepticus (SE) are limited. The pharmacokinetics of levetiracetam (LEV) after rectal administration in both healthy and epileptic dogs has been investigated recently. HYPOTHESIS/OBJECTIVES: To investigate the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639497/ https://www.ncbi.nlm.nih.gov/pubmed/31218767 http://dx.doi.org/10.1111/jvim.15541 |
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author | Cagnotti, Giulia Odore, Rosangela Bertone, Iride Corona, Cristiano Dappiano, Elena Gardini, Giulia Iulini, Barbara Bellino, Claudio D'Angelo, Antonio |
author_facet | Cagnotti, Giulia Odore, Rosangela Bertone, Iride Corona, Cristiano Dappiano, Elena Gardini, Giulia Iulini, Barbara Bellino, Claudio D'Angelo, Antonio |
author_sort | Cagnotti, Giulia |
collection | PubMed |
description | BACKGROUND: Treatment options for at‐home management of cluster seizures (CS) and status epilepticus (SE) are limited. The pharmacokinetics of levetiracetam (LEV) after rectal administration in both healthy and epileptic dogs has been investigated recently. HYPOTHESIS/OBJECTIVES: To investigate the clinical efficacy of rectally administered LEV in preventing additional seizures in dogs presented for CS and SE. We hypothesized that rectal administration of LEV in addition to a standard treatment protocol would provide better control of seizure activity as compared with the standard treatment protocol alone. ANIMALS: Fifty‐seven client‐owned dogs with CS or SE. METHODS: Prospective open‐label clinical trial. Patients included in the study were assigned to receive either a standard treatment protocol comprising IV/rectal diazepam and IV phenobarbital q8h (control group) or a standard treatment protocol in association with a single dose of 40 mg/kg LEV rectally (rectal LEV group). Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders. RESULTS: Twenty‐one dogs were assigned to the rectal LEV group, and 36 to control group. Given the small number of cases of SE, statistical analysis was performed only on patients with CS. The response rate was 94% in the rectal LEV group and 48% in the control group (P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Rectally administered LEV combined with a standard treatment protocol provided good control of seizure activity in patients with CS. The validity of these results should be confirmed in a double‐blinded, placebo‐controlled clinical trial. |
format | Online Article Text |
id | pubmed-6639497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66394972019-07-29 Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures Cagnotti, Giulia Odore, Rosangela Bertone, Iride Corona, Cristiano Dappiano, Elena Gardini, Giulia Iulini, Barbara Bellino, Claudio D'Angelo, Antonio J Vet Intern Med SMALL ANIMAL BACKGROUND: Treatment options for at‐home management of cluster seizures (CS) and status epilepticus (SE) are limited. The pharmacokinetics of levetiracetam (LEV) after rectal administration in both healthy and epileptic dogs has been investigated recently. HYPOTHESIS/OBJECTIVES: To investigate the clinical efficacy of rectally administered LEV in preventing additional seizures in dogs presented for CS and SE. We hypothesized that rectal administration of LEV in addition to a standard treatment protocol would provide better control of seizure activity as compared with the standard treatment protocol alone. ANIMALS: Fifty‐seven client‐owned dogs with CS or SE. METHODS: Prospective open‐label clinical trial. Patients included in the study were assigned to receive either a standard treatment protocol comprising IV/rectal diazepam and IV phenobarbital q8h (control group) or a standard treatment protocol in association with a single dose of 40 mg/kg LEV rectally (rectal LEV group). Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders. RESULTS: Twenty‐one dogs were assigned to the rectal LEV group, and 36 to control group. Given the small number of cases of SE, statistical analysis was performed only on patients with CS. The response rate was 94% in the rectal LEV group and 48% in the control group (P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Rectally administered LEV combined with a standard treatment protocol provided good control of seizure activity in patients with CS. The validity of these results should be confirmed in a double‐blinded, placebo‐controlled clinical trial. John Wiley & Sons, Inc. 2019-06-20 2019 /pmc/articles/PMC6639497/ /pubmed/31218767 http://dx.doi.org/10.1111/jvim.15541 Text en © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Cagnotti, Giulia Odore, Rosangela Bertone, Iride Corona, Cristiano Dappiano, Elena Gardini, Giulia Iulini, Barbara Bellino, Claudio D'Angelo, Antonio Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
title | Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
title_full | Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
title_fullStr | Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
title_full_unstemmed | Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
title_short | Open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
title_sort | open‐label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639497/ https://www.ncbi.nlm.nih.gov/pubmed/31218767 http://dx.doi.org/10.1111/jvim.15541 |
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