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Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

Aptamers are a class of single oligonucleotide molecules (DNA or RNA) that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment technology. The selected aptamers are capable of specifically binding to different targeting m...

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Autores principales: Zhang, Guo-Qing, Zhong, Li-Ping, Yang, Nuo, Zhao, Yong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639558/
https://www.ncbi.nlm.nih.gov/pubmed/31341361
http://dx.doi.org/10.3748/wjg.v25.i26.3359
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author Zhang, Guo-Qing
Zhong, Li-Ping
Yang, Nuo
Zhao, Yong-Xiang
author_facet Zhang, Guo-Qing
Zhong, Li-Ping
Yang, Nuo
Zhao, Yong-Xiang
author_sort Zhang, Guo-Qing
collection PubMed
description Aptamers are a class of single oligonucleotide molecules (DNA or RNA) that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment technology. The selected aptamers are capable of specifically binding to different targeting molecules, which is achieved by the three-dimensional structure of aptamers. Aptamers are similar in function to monoclonal antibodies, and therefore, they are also referred to as "chemical antibodies". Due to their high affinity and specificity and low immunogenicity, aptamers are topics of intense interest in today's biological targeting research especially in tumor research. They not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor therapy. Various experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for application. This paper summarizes the structure, characteristics, and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer.
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spelling pubmed-66395582019-07-24 Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer Zhang, Guo-Qing Zhong, Li-Ping Yang, Nuo Zhao, Yong-Xiang World J Gastroenterol Minireviews Aptamers are a class of single oligonucleotide molecules (DNA or RNA) that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment technology. The selected aptamers are capable of specifically binding to different targeting molecules, which is achieved by the three-dimensional structure of aptamers. Aptamers are similar in function to monoclonal antibodies, and therefore, they are also referred to as "chemical antibodies". Due to their high affinity and specificity and low immunogenicity, aptamers are topics of intense interest in today's biological targeting research especially in tumor research. They not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor therapy. Various experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for application. This paper summarizes the structure, characteristics, and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer. Baishideng Publishing Group Inc 2019-07-14 2019-07-14 /pmc/articles/PMC6639558/ /pubmed/31341361 http://dx.doi.org/10.3748/wjg.v25.i26.3359 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Zhang, Guo-Qing
Zhong, Li-Ping
Yang, Nuo
Zhao, Yong-Xiang
Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
title Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
title_full Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
title_fullStr Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
title_full_unstemmed Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
title_short Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
title_sort screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639558/
https://www.ncbi.nlm.nih.gov/pubmed/31341361
http://dx.doi.org/10.3748/wjg.v25.i26.3359
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