Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab

We report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of Stenotrophomonas maltophilia and Ps...

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Detalles Bibliográficos
Autores principales: Musameh, K., Campbell, C.D., Rutherford, R.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639681/
https://www.ncbi.nlm.nih.gov/pubmed/31360633
http://dx.doi.org/10.1016/j.rmcr.2019.100904
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author Musameh, K.
Campbell, C.D.
Rutherford, R.M.
author_facet Musameh, K.
Campbell, C.D.
Rutherford, R.M.
author_sort Musameh, K.
collection PubMed
description We report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of Stenotrophomonas maltophilia and Pseudomonas aeruginosa and marked radiological deterioration in BE. She was found to have a low serum IgG and IgM levels almost certainly as a complication of Rituximab. Immunoglobulin replacement therapy was instituted and her clinical status has slowly improved.
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spelling pubmed-66396812019-07-29 Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab Musameh, K. Campbell, C.D. Rutherford, R.M. Respir Med Case Rep Case Report We report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of Stenotrophomonas maltophilia and Pseudomonas aeruginosa and marked radiological deterioration in BE. She was found to have a low serum IgG and IgM levels almost certainly as a complication of Rituximab. Immunoglobulin replacement therapy was instituted and her clinical status has slowly improved. Elsevier 2019-07-11 /pmc/articles/PMC6639681/ /pubmed/31360633 http://dx.doi.org/10.1016/j.rmcr.2019.100904 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Musameh, K.
Campbell, C.D.
Rutherford, R.M.
Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_full Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_fullStr Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_full_unstemmed Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_short Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_sort marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with rituximab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639681/
https://www.ncbi.nlm.nih.gov/pubmed/31360633
http://dx.doi.org/10.1016/j.rmcr.2019.100904
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