Human Albumin Impairs Amyloid β-peptide Fibrillation Through its C-terminus: From docking Modeling to Protection Against Neurotoxicity in Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate into β-sheets that are neurotoxic. Therefore to prevent or delay AD onset...

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Detalles Bibliográficos
Autores principales: Picón-Pagès, Pol, Bonet, Jaume, García-García, Javier, Garcia-Buendia, Joan, Gutierrez, Daniela, Valle, Javier, Gómez-Casuso, Carmen E.S., Sidelkivska, Valeriya, Alvarez, Alejandra, Perálvarez-Marín, Alex, Suades, Albert, Fernàndez-Busquets, Xavier, Andreu, David, Vicente, Rubén, Oliva, Baldomero, Muñoz, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639691/
https://www.ncbi.nlm.nih.gov/pubmed/31360335
http://dx.doi.org/10.1016/j.csbj.2019.06.017

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