Cargando…

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

[Image: see text] Drugs capable of ameliorating symptoms of depression and anxiety while also improving cognitive function and sociability are highly desirable. Anecdotal reports have suggested that serotonergic psychedelics administered in low doses on a chronic, intermittent schedule, so-called “m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cameron, Lindsay P., Benson, Charlie J., DeFelice, Brian C., Fiehn, Oliver, Olson, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639775/ https://www.ncbi.nlm.nih.gov/pubmed/30829033 http://dx.doi.org/10.1021/acschemneuro.8b00692

Ejemplares similares

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT
por: Barker, Steven A.
Publicado: (2022)

Phenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience
por: Lawrence, David Wyndham, et al.
Publicado: (2022)

Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
por: Dean, Jon G., et al.
Publicado: (2019)

Asking questions of psychedelic microdosing
por: Cameron, Lindsay P
Publicado: (2021)

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
por: Barker, Steven A.
Publicado: (2018)

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
por: Brito-da-Costa, Andreia Machado, et al.
Publicado: (2020)

The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT)
por: Reckweg, Johannes T., et al.
Publicado: (2022)

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells
por: Szabo, Attila, et al.
Publicado: (2014)

Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N‐dimethyltryptamine – Implications for dose considerations
por: Eckernäs, Emma, et al.
Publicado: (2022)

Dimethyltryptamine (DMT): a biochemical Swiss Army knife in neuroinflammation and neuroprotection?
por: Szabo, Attila, et al.
Publicado: (2016)

A systematic study of microdosing psychedelics
por: Polito, Vince, et al.
Publicado: (2019)

The therapeutic potential of microdosing psychedelics in depression
por: Kuypers, Kim P.C.
Publicado: (2020)

Pharmacokinetics of N,N-dimethyltryptamine in Humans
por: Good, Meghan, et al.
Publicado: (2023)

Optimized infusion rates for N,N‐dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework
por: Eckernäs, Emma, et al.
Publicado: (2023)

Psychedelic microdosing benefits and challenges: an empirical codebook
por: Anderson, Thomas, et al.
Publicado: (2019)

Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions
por: Dunlap, Lee E., et al.
Publicado: (2018)

Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers
por: Hutten, Nadia R. P. W., et al.
Publicado: (2019)

Motives and Side-Effects of Microdosing With Psychedelics Among Users
por: Hutten, Nadia R P W, et al.
Publicado: (2019)

Self-blinding citizen science to explore psychedelic microdosing
por: Szigeti, Balázs, et al.
Publicado: (2021)

Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
por: Rootman, Joseph M., et al.
Publicado: (2021)

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
por: James, Edward, et al.
Publicado: (2022)

Powerful substances in tiny amounts: An interview study of psychedelic microdosing
por: Johnstad, Petter Grahl
Publicado: (2018)

Experiences of microdosing psychedelics in an attempt to support wellbeing and mental health
por: Ryan, Rebecca S., et al.
Publicado: (2023)

Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptamine and N,N-Dimethylaminopropyltryptamine
por: Chu, Uyen B., et al.
Publicado: (2014)

Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting
por: Prochazkova, Luisa, et al.
Publicado: (2018)

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research
por: Kuypers, Kim PC, et al.
Publicado: (2019)

Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
por: Kaertner, L. S., et al.
Publicado: (2021)

Indolethylamine-N-methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous N,N,-dimethyltryptamine
por: Dean, Jon G.
Publicado: (2018)

Detection and Quantification of Psychoactive N,N-Dimethyltryptamine in Ayahuasca Brews by Ambient Ionization High-Resolution Mass Spectrometry
por: Chambers, Megan I., et al.
Publicado: (2020)

The difference between ‘placebo group’ and ‘placebo control’: a case study in psychedelic microdosing
por: Szigeti, Balázs, et al.
Publicado: (2023)

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls
por: Rootman, Joseph M., et al.
Publicado: (2022)

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells
por: Szabo, Attila, et al.
Publicado: (2016)

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
por: Morales-Garcia, Jose A., et al.
Publicado: (2020)

The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin
por: Chadeayne, Andrew R., et al.
Publicado: (2019)

A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience
por: Gallimore, Andrew R., et al.
Publicado: (2016)

N,N‐dimethyltryptamine affects electroencephalography response in a concentration‐dependent manner—A pharmacokinetic/pharmacodynamic analysis
por: Eckernäs, Emma, et al.
Publicado: (2023)

Author Correction: Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls
por: Rootman, Joseph M., et al.
Publicado: (2022)

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms
por: Uthaug, M. V., et al.
Publicado: (2019)

Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders
por: Lowe, Henry, et al.
Publicado: (2022)

Twenty percent better with 20 micrograms? A qualitative study of psychedelic microdosing self-rapports and discussions on YouTube
por: Andersson, Martin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lcemib6l6t0r8e30gpavcdtso4