‘PARAMEDIC-2: Big study, small result’

The PARAMEDIC-2 trial demonstrated that the use of adrenaline compared with placebo in out-of-hospital cardiac arrest (OHCA) resulted in a small increase in 30-day survival, but was associated with a higher number of survivors with severe neurological impairment. These findings received a lot of att...

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Detalles Bibliográficos
Autores principales: ter Avest, E., Lameijer, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bohn Stafleu van Loghum 2019
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639839/
https://www.ncbi.nlm.nih.gov/pubmed/31278638
http://dx.doi.org/10.1007/s12471-019-1302-x
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author ter Avest, E.
Lameijer, H.
author_facet ter Avest, E.
Lameijer, H.
author_sort ter Avest, E.
collection PubMed
description The PARAMEDIC-2 trial demonstrated that the use of adrenaline compared with placebo in out-of-hospital cardiac arrest (OHCA) resulted in a small increase in 30-day survival, but was associated with a higher number of survivors with severe neurological impairment. These findings received a lot of attention, and generated a widespread discussion about the role of adrenaline in cardiac arrest. In this point of view, we aim to place the PARAMEDIC-2 results in the right perspective by comparing the relative effect of adrenaline to other determinants of cerebral blood flow.
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spelling pubmed-66398392019-08-01 ‘PARAMEDIC-2: Big study, small result’ ter Avest, E. Lameijer, H. Neth Heart J Point of View The PARAMEDIC-2 trial demonstrated that the use of adrenaline compared with placebo in out-of-hospital cardiac arrest (OHCA) resulted in a small increase in 30-day survival, but was associated with a higher number of survivors with severe neurological impairment. These findings received a lot of attention, and generated a widespread discussion about the role of adrenaline in cardiac arrest. In this point of view, we aim to place the PARAMEDIC-2 results in the right perspective by comparing the relative effect of adrenaline to other determinants of cerebral blood flow. Bohn Stafleu van Loghum 2019-07-05 2019-07 /pmc/articles/PMC6639839/ /pubmed/31278638 http://dx.doi.org/10.1007/s12471-019-1302-x Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Point of View
ter Avest, E.
Lameijer, H.
‘PARAMEDIC-2: Big study, small result’
title ‘PARAMEDIC-2: Big study, small result’
title_full ‘PARAMEDIC-2: Big study, small result’
title_fullStr ‘PARAMEDIC-2: Big study, small result’
title_full_unstemmed ‘PARAMEDIC-2: Big study, small result’
title_short ‘PARAMEDIC-2: Big study, small result’
title_sort ‘paramedic-2: big study, small result’
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639839/
https://www.ncbi.nlm.nih.gov/pubmed/31278638
http://dx.doi.org/10.1007/s12471-019-1302-x
work_keys_str_mv AT teraveste paramedic2bigstudysmallresult
AT lameijerh paramedic2bigstudysmallresult

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