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Effect of vitamin D status on normal fertilization rate following in vitro fertilization

BACKGROUND: Vitamin D plays critical role in the female reproductive system. It seems that vitamin D is associated with clinical pregnancy outcomes of assisted reproductive technologies (ART), but its role remains elusive. This study is aimed to establish whether vitamin D is associated with clinica...

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Autores principales: Liu, Xuemei, Zhang, Wei, Xu, Yanping, Chu, Yongli, Wang, Xinrong, Li, Qian, Ma, Zhi, Liu, Zhenteng, Wan, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639905/
https://www.ncbi.nlm.nih.gov/pubmed/31319865
http://dx.doi.org/10.1186/s12958-019-0500-0
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author Liu, Xuemei
Zhang, Wei
Xu, Yanping
Chu, Yongli
Wang, Xinrong
Li, Qian
Ma, Zhi
Liu, Zhenteng
Wan, Yanling
author_facet Liu, Xuemei
Zhang, Wei
Xu, Yanping
Chu, Yongli
Wang, Xinrong
Li, Qian
Ma, Zhi
Liu, Zhenteng
Wan, Yanling
author_sort Liu, Xuemei
collection PubMed
description BACKGROUND: Vitamin D plays critical role in the female reproductive system. It seems that vitamin D is associated with clinical pregnancy outcomes of assisted reproductive technologies (ART), but its role remains elusive. This study is aimed to establish whether vitamin D is associated with clinical outcomes of in vitro fertilization (IVF). METHODS: The cross-sectional study was carried out from January 1st 2017 to December 31st 2017. A total of 848 patients who had indications for IVF were enrolled. The patients were classified by serum 25 (OH) D quartiles. The outcome parameters of IVF were compared in each group, including normal fertilization rate, high quality embryo rate, clinical pregnancy rate, implantation rate and live birth rate. RESULTS: The median 25 (OH) D concentration was 15.25 ng/ml. Serum 25 (OH) D levels in women varied with the seasons. We found that serum 25 (OH) D levels were higher in autumn than other seasons, and the lowest level occurred in spring. Follicular fluid (FF) vitamin D levels were positively correlated with serum vitamin D levels (r = 0.85, P < 0.001). The levels of FF vitamin D were significantly higher than the levels of serum vitamin D (P < 0.001). Normal fertilization rates were significantly different among four groups (P = 0.007). The group of women with the highest serum 25 (OH) D levels had the highest normal fertilization rate. However, the clinical pregnancy rate, implantation rate and live birth rates were not significantly different among the four groups when the age, BMI, AMH, seasons of blood drawing, COH protocol, high quality embryo rate and number of embryos transferred were adjusted. In addition, we found that serum 25 (OH) D levels were significantly higher in patients received IVF than patients received R-ICSI (P = 0.013). CONCLUSIONS: Among Chinese women, lower serum vitamin D levels are associated with a lower fertilization rate in IVF. However, vitamin D level was not associated with the clinical pregnancy and live birth rate following IVF. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12958-019-0500-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-66399052019-07-29 Effect of vitamin D status on normal fertilization rate following in vitro fertilization Liu, Xuemei Zhang, Wei Xu, Yanping Chu, Yongli Wang, Xinrong Li, Qian Ma, Zhi Liu, Zhenteng Wan, Yanling Reprod Biol Endocrinol Research BACKGROUND: Vitamin D plays critical role in the female reproductive system. It seems that vitamin D is associated with clinical pregnancy outcomes of assisted reproductive technologies (ART), but its role remains elusive. This study is aimed to establish whether vitamin D is associated with clinical outcomes of in vitro fertilization (IVF). METHODS: The cross-sectional study was carried out from January 1st 2017 to December 31st 2017. A total of 848 patients who had indications for IVF were enrolled. The patients were classified by serum 25 (OH) D quartiles. The outcome parameters of IVF were compared in each group, including normal fertilization rate, high quality embryo rate, clinical pregnancy rate, implantation rate and live birth rate. RESULTS: The median 25 (OH) D concentration was 15.25 ng/ml. Serum 25 (OH) D levels in women varied with the seasons. We found that serum 25 (OH) D levels were higher in autumn than other seasons, and the lowest level occurred in spring. Follicular fluid (FF) vitamin D levels were positively correlated with serum vitamin D levels (r = 0.85, P < 0.001). The levels of FF vitamin D were significantly higher than the levels of serum vitamin D (P < 0.001). Normal fertilization rates were significantly different among four groups (P = 0.007). The group of women with the highest serum 25 (OH) D levels had the highest normal fertilization rate. However, the clinical pregnancy rate, implantation rate and live birth rates were not significantly different among the four groups when the age, BMI, AMH, seasons of blood drawing, COH protocol, high quality embryo rate and number of embryos transferred were adjusted. In addition, we found that serum 25 (OH) D levels were significantly higher in patients received IVF than patients received R-ICSI (P = 0.013). CONCLUSIONS: Among Chinese women, lower serum vitamin D levels are associated with a lower fertilization rate in IVF. However, vitamin D level was not associated with the clinical pregnancy and live birth rate following IVF. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12958-019-0500-0) contains supplementary material, which is available to authorized users. BioMed Central 2019-07-18 /pmc/articles/PMC6639905/ /pubmed/31319865 http://dx.doi.org/10.1186/s12958-019-0500-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Liu, Xuemei
Zhang, Wei
Xu, Yanping
Chu, Yongli
Wang, Xinrong
Li, Qian
Ma, Zhi
Liu, Zhenteng
Wan, Yanling
Effect of vitamin D status on normal fertilization rate following in vitro fertilization
title Effect of vitamin D status on normal fertilization rate following in vitro fertilization
title_full Effect of vitamin D status on normal fertilization rate following in vitro fertilization
title_fullStr Effect of vitamin D status on normal fertilization rate following in vitro fertilization
title_full_unstemmed Effect of vitamin D status on normal fertilization rate following in vitro fertilization
title_short Effect of vitamin D status on normal fertilization rate following in vitro fertilization
title_sort effect of vitamin d status on normal fertilization rate following in vitro fertilization
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639905/
https://www.ncbi.nlm.nih.gov/pubmed/31319865
http://dx.doi.org/10.1186/s12958-019-0500-0
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